Age-related differences in myeloarchitecture measured at 7 T

NEUROBIOLOGY OF AGING

卷:96

Article

Carradus, Andrew J.¹  Mougin, Olivier¹  Hunt, Benjamin A. E.¹  Tewarie, Prejaas K.¹  Geades, Nicolas²  Morris, Peter G.¹  Brookes, Matthew J.¹  Gowland, Penny A.¹  Madan, Christopher R.^1,3 

[1] Univ Nottingham, Sir Peter Mansfield Imaging Ctr, Sch Phys & Astron, Nottingham, England

[2] Philips Healthcare, Philips Clin Sci, Eindhoven, Netherlands

[3] Univ Nottingham, Sch Psychol, Univ Pk, Nottingham NG7 2RD, England

关键词: Aging;    Brain structure;    Myelin;    MT;    7 tesla;    Gray matter;   

DOI  :  10.1016/j.neurobiolaging.2020.08.009

来源: Elsevier

【 摘 要 】

We have used the magnetisation transfer (MT) MRI measure as a primary measure of myelination in both the gray matter (GM) of the 78 cortical automated anatomical labeling (AAL) regions of the brain, and the underlying white matter in each region, in a cohort of healthy adults (aged 19-62 year old). The results revealed a significant quadratic trend in myelination with age, with average global myelination peaking at 42.9 year old in gray matter, and at 41.7 year old in white matter. We also explored the possibility of using the Nuclear Overhauser Enhancement (NOE) effect, which is acquired in a similar method to MT, as an additional measure of myelination. We found that the MT and NOE signals were strongly correlated in the brain and that the NOE effects displayed similar (albeit weaker) parabolic trends with age. We also investigated differences in cortical thickness with age, and confirmed a previous result of a linear decline of 4.5 +/- 1.2 mu m/y. (C) 2020 Elsevier Inc. All rights reserved.

【 授权许可】

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