Cognitive response to fish oil, blueberry, and combined supplementation in older adults with subjective cognitive impairment

NEUROBIOLOGY OF AGING

卷:64

Article

McNamara, Robert K.¹  Kalt, Wilhelmina²  Shidler, Marcelle D.¹  McDonald, Jane²  Summerc, Suzanne S.³  Stein, Amanda L.¹  Stover, Amanda N.¹  Krikorian, Robert¹ 

[1] Univ Cincinnati, Acad Hlth Ctr, Dept Psychiat & Behav Neurosci, POB 670559, Cincinnati, OH 45267 USA

[2] Agr & Agri Food Canada, Kentville Res & Dev Ctr, Kentville, NS, Canada

[3] Cincinnati Childrens Hosp Med Ctr, Clin Translat Res Ctr, Cincinnati, OH 45229 USA

关键词: Omega-3 fatty acids;    Blueberries;    Anthocyanins;    Aging;    Memory;    Dementia;   

DOI  :  10.1016/j.neurobiolaging.2017.12.003

来源: Elsevier

【 摘 要 】

Given evidence that eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and anthocyanin-rich blueberries provide neurocognitive benefit, we investigated long-term supplementation in older adults with cognitive complaints. In a 24-week randomized, double-blind, placebo-controlled trial, elderly men and women received daily fish oil (FO) or blueberry (BB) or both. Diet records confirmed that participants reduced background consumption of EPA, DHA, and anthocyanins as prescribed. Erythrocyte EPA thorn DHA composition increased in the FO groups (p = 0.0001). Total urinary anthocyanins did not differ between the groups after supplementation but glycoside and native (food) forms increased only in the BB-supplemented groups. The FO (p = 0.03) and BB (p = 0.05) groups reported fewer cognitive symptoms, and the BB group showed improved memory discrimination (p = 0.04), indicating that supplementation improved cognition. Cognitive benefit in the BB group was associated with the presence of urinary anthocyanins reflecting recent BB intake but not with anthocyanin metabolites. However, combined FO thorn BB treatment was not associated with cognitive enhancement as expected. (C) 2017 Elsevier Inc. All rights reserved.

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