Serum and cerebrospinal fluid Neutrophil gelatinase-associated lipocalin (NGAL) levels as biomarkers for the conversion from mild cognitive impairment to Alzheimer's disease dementia

NEUROBIOLOGY OF AGING

卷:107

Article

Naude, Petrus J. W.^1,2,3,4,5  Ramakers, Inez H. G. B.⁶  van der Flier, Wiesje M.^7,8  Jiskoot, Lize C.^9,10  Reesink, Fransje E.^1,2  Claassen, Jurgen A. H. R.^11,12  Koek, Huiberdina L.^13,14  Eisel, Ulrich L. M.^3,15,16  De Deyn, Peter P.^1,2,17 

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Neurol, Hanzepl 1, NL-9713 GZ Groningen, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, Alzheimer Res Ctr, Hanzepl 1, NL-9713 GZ Groningen, Netherlands

[3] Univ Groningen, Groningen Inst Evolutionary Life Sci GELIFES, Dept Mol Neurobiol, Groningen, Netherlands

[4] Univ Cape Town, Dept Psychiat, Cape Town, South Africa

[5] Univ Cape Town, Mental Hlth & Neurosci Inst, Brain Behav Unit, Cape Town, South Africa

[6] Maastricht Univ, Med Ctr, Alzheimer Ctr Limburg, Sch Mental Hlth & Neurosci MHeNS, Maastricht, Netherlands

[7] Vrije Univ Amsterdam, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands

[8] Vrije Univ Amsterdam, Dept Epidemiol & Data Sci, Amsterdam UMC, Amsterdam, Netherlands

[9] Erasmus MC, Dept Neurol, Rotterdam, Netherlands

[10] UCL, Dementia Res Ctr, London, England

[11] Radboud Univ Nijmegen, Med Ctr, Nijmegen, Netherlands

[12] Radboud Alzheimer Ctr, Dept Geriatr, Nijmegen, Netherlands

[13] Univ Med Ctr Utrecht, Dept Neurol, Utrecht, Netherlands

[14] Univ Med Ctr Utrecht, Dept Geriatr, Utrecht, Netherlands

[15] Univ Groningen, Univ Med Ctr Groningen, Univ Ctr Psychiat, Groningen, Netherlands

[16] Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol Emot Regulat, Groningen, Netherlands

[17] Univ Antwerp, Biobank, Inst Born Bunge, Lab Neurochem & Behav, Antwerp, Belgium

关键词: Neuroinflammation;    Amyloid beta;    Follow-up;    Converters;    Lipocalin 2;    Prodromal, Biomarker;   

DOI  :  10.1016/j.neurobiolaging.2021.07.001

来源: Elsevier

【 摘 要 】

Neutrophil gelatinase-associated lipocalin (NGAL) is an acute phase protein that has been reported as a potential marker for pre-dementia stages of Alzheimer's disease (AD). Longitudinal studies for its association with the conversion of mild cognitive impairment to AD is still lacking. This study included n = 268 study participants with subjective cognitive decline (SCD) (n = 82), mild cognitive impairment (MCI) (n = 98) and AD dementia (n = 88) at baseline and two-year follow-up clinical assessments. Serum and cerebrospinal fluid (CSF)NGAL, CSF amyloid beta(1-42), total-Tau, and phospho-Tau levels were measured with ELISA analysis. CSF NGAL levels were significantly lower in MCI participants compared to people with SCD at baseline. Lower baseline CSF NGAL levels predicted MCI converters to AD dementia vs. non-converters after 2-years follow-up. A positive correlation between CSF NGAL and amyloid beta(1-42) was found particularly in MCI participants at baseline. NGAL in CSF holds potential to be used as a predictive marker for the conversion of MCI to AD dementia and may reflect pathophysiological processes of prodromal AD neuropathology. (C) 2021 The Authors. Published by Elsevier Inc.

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