Influence of structural and functional brain connectivity on age-related differences in fluid cognition

NEUROBIOLOGY OF AGING

卷:96

Article

Madden, David J.^1,2,3  Jain, Shivangi¹  Monge, Zachary A.^1,3  Cook, Angela D.¹  Lee, Alexander¹  Huang, Hua¹  Howard, Cortney M.^1,3  Cohen, Jessica R.^1,4 

[1] Duke Univ, Med Ctr, Brain Imaging & Anal Ctr, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27710 USA

[3] Duke Univ, Ctr Cognit Neurosci, Durham, NC 27710 USA

[4] Univ North Carolina Chapel Hill, Dept Psychol & Neurosci, Chapel Hill, NC USA

关键词: Graph theory;    System segregation;    Brain connectome;    Magnetic resonance imaging;    Executive function;    Statistical mediation;   

DOI  :  10.1016/j.neurobiolaging.2020.09.010

来源: Elsevier

【 摘 要 】

We used graph theoretical measures to investigate the hypothesis that structural brain connectivity constrains the influence of functional connectivity on the relation between age and fluid cognition. Across 143 healthy, community-dwelling adults 19-79 years of age, we estimated structural network properties from diffusion-weighted imaging and functional network properties from resting-state functional magnetic resonance imaging. We confirmed previous reports of age-related decline in the strength and efficiency of structural networks, as well as in the connectivity strength within and between structural network modules. Functional networks, in contrast, exhibited age-related decline only in system segregation, a measure of the distinctiveness among network modules. Aging was associated with decline in a composite measure of fluid cognition, particularly tests of executive function. Functional system segregation was a significant mediator of age-related decline in executive function. Structural network properties did not directly influence the age-related decline in functional system segregation. The raw correlational data underlying the graph theoretical measures indicated that structural connectivity exerts a limited constraint on age-related decline in functional connectivity. (C) 2020 The Author(s). Published by Elsevier Inc.

【 授权许可】

Free