Preservation of hippocampal neuron numbers in aged rhesus monkeys

NEUROBIOLOGY OF AGING

卷:24

Article

Keuker, JIH ; Luiten, PGM ; Fuchs, E

关键词: aging;    rhesus monkey;    hippocampal formation;    neuron number;    stereology;    optical fractionator;   

DOI  :  10.1016/S0197-4580(02)00062-3

来源: Elsevier

【 摘 要 】

To investigate whether or not aging of nonhuman primates is accompanied by a region-specific neuron loss in the hippocampal formation, we used the optical fractionator technique to obtain stereological estimates of unilateral neuron numbers of the hippocampi of eight young (0-4 years) and five aged (18-31 years) male rhesus monkeys (Macaca mulatta). Our results show a preservation of neurons (mean x 10(3) S.D. x 10(3)) in the subiculum (young = 588 +/- 124, aged = 612 +/- 207), CA1 (young = 1051 +/- 249, aged = 1318 +/- 311), CA2 (young 100 +/- 18, aged = 113 +/- 12), CA3 (young = 478 +/- 125, aged = 509 +/- 139), hilus (young = 337 +/- 115, aged = 394 +/- 90), and dentate gyrus (young = 5550 +/- 1725, aged = 7799 +/- 2087) of the hippocampal formation. These results confirm a previous stereological study in rhesus monkeys, but are in conflict with data for humans, showing age-dependent region-specific alterations in the hippocampal formation. (C) 2002 Elsevier Science Inc. All rights reserved.

【 授权许可】

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