Genome-wide association identifies a novel locus for delirium risk

NEUROBIOLOGY OF AGING

卷:68

Article

McCoy, Thomas H., Jr.^1,2,3  Hart, Kamber^1,2,3  Pellegrini, Amelia^1,2,3  Perlis, Roy H.^1,2,3 

[1] Massachusetts Gen Hosp, Ctr Quantitat Hlth, Boston, MA 02114 USA

[2] Harvard Med Sch, Boston, MA 02114 USA

[3] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA

关键词: Genetic association;    Delirium;    Consultation psychiatry;    Attention;    Biobank;   

DOI  :  10.1016/j.neurobiolaging.2018.03.008

来源: Elsevier

【 摘 要 】

We aimed to identify common genetic variations associated with delirium through genome-wide association testing in a hospital biobank. We applied a published electronic health record-based definition of delirium to identify cases of delirium, and control individuals with no history of delirium, from a biobank spanning 2 Boston academic medical centers. Among 6035 individuals of northern European ancestry, including 421 with a history of delirium, we used logistic regression to examine genome-wide association. We identified one locus spanning multiple genes, including 3 interleukin-related genes, associated with p = 1.41e-8, and 5 other independent loci with p < 5e-7. Our results do not support previously reported candidate gene associations in delirium. Identifying common-variant associations with delirium may provide insight into the mechanisms responsible for this complex and multifactorial outcome. Using standardized claims-based phenotypes in biobanks should allow the larger scale investigations required to confirm novel loci such as the one we identify. (C) 2018 Elsevier Inc. All rights reserved.

【 授权许可】

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