Aging faster: worry and rumination in late life are associated with greater brain age

NEUROBIOLOGY OF AGING

卷:101

Article

Karim, Helmet T.¹  Ly, Maria²  Yu, Gary³  Krafty, Robert⁴  Tudorascu, Dana L.^1,4  Aizenstein, Howard J.^1,3  Andreescu, Carmen¹ 

[1] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA

[2] Univ Pittsburgh, Dept Neurosci, Pittsburgh, PA USA

[3] Univ Pittsburgh, Dept Bioengn, Pittsburgh, PA USA

[4] Univ Pittsburgh, Dept Biostat, Pittsburgh, PA 15261 USA

关键词: Worry;    Rumination;    Anxiety;    Generalized anxiety disorder;    Late life;    Brain age;    Accelerated aging;   

DOI  :  10.1016/j.neurobiolaging.2021.01.009

来源: Elsevier

【 摘 要 】

Older adults with anxiety have lower gray matter brain volumeda component of accelerated aging. We have previously validated a machine learning model to predict brain age, an estimate of an individual's age based on voxel-wise gray matter images. We investigated associations between brain age and anxiety, depression, stress, and emotion regulation. We recruited 78 participants (>50 years) along a wide range of worry severity. We collected imaging data and computed voxel-wise gray matter images, which were input into an existing machine learning model to estimate brain age. We conducted a multivariable linear regression between brain age and age, sex, race, education, worry, anxiety, depression, rumination, neuroticism, stress, reappraisal, and suppression. We found that greater brain age was significantly associated with greater age, male sex, greater worry, greater rumination, and lower suppression. Male sex, worry, and rumination are associated with accelerated aging in late life and expressive suppression may have a protective effect. These results provide evidence for the trans diagnostic model of negative repetitive thoughts, which are associated with cognitive decline, amyloid, and tau. Published by Elsevier Inc.

【 授权许可】

Free