Age-related changes in the functional neuroanatomy of overt speech production

NEUROBIOLOGY OF AGING

卷:32

Article

Soeroes, Peter¹  Bose, Arpita²  Sokoloff, Lisa Guttman^3,4  Graham, Simon J.^1,5,6,7  Stuss, Donald T.^4,7,8,9 

[1] Sunnybrook Hlth Sci Ctr, Toronto, ON M4N 3M5, Canada

[2] Univ Windsor, Dept Psychol, Windsor, ON N9B 3P4, Canada

[3] Baycrest, Commun Disorders, Toronto, ON, Canada

[4] Univ Toronto, Dept Speech Language Pathol, Toronto, ON M5S 1A1, Canada

[5] Baycrest, Rotman Res Inst, Toronto, ON, Canada

[6] Univ Toronto, Dept Med Biophys, Toronto, ON M5S 1A1, Canada

[7] Heart & Stroke Fdn, Ontario Ctr Stroke Recovery, Toronto, ON, Canada

[8] Univ Toronto, Dept Psychol, Toronto, ON M5S 1A1, Canada

[9] Univ Toronto, Dept Med Neurol Rehabil Sci, Toronto, ON M5S 1A1, Canada

关键词: Healthy aging;    Speech;    Plasticity;    Reorganization;    Functional magnetic resonance imaging;    Brain;    Cortex;   

DOI  :  10.1016/j.neurobiolaging.2009.08.015

来源: Elsevier

【 摘 要 】

Alterations of existing neural networks during healthy aging, resulting in behavioral deficits and changes in brain activity, have been described for cognitive, motor, and sensory functions. To investigate age-related changes in the neural circuitry underlying overt non-lexical speech production, functional MRI was performed in 14 healthy younger (21-32years) and 14 healthy older individuals (62-84years). The experimental task involved the acoustically cued overt production of the vowel /a/ and the polysyllabic utterance /pataka/. In younger and older individuals, overt speech production was associated with the activation of a widespread articulo-phonological network, including the primary motor cortex, the supplementary motor area, the cingulate motor areas, and the posterior superior temporal cortex, similar in the /a/ and /pataka/ condition. An analysis of variance with the factors age and condition revealed a significant main effect of age. Irrespective of the experimental condition, significantly greater activation was found in the bilateral posterior superior temporal cortex, the posterior temporal plane, and the transverse temporal gyri in younger compared to older individuals. Significantly greater activation was found in the bilateral middle temporal gyri, medial frontal gyri, middle frontal gyri, and inferior frontal gyri in older vs. younger individuals. The analysis of variance did not reveal a significant main effect of condition and no significant interaction of age and condition. These results suggest a complex reorganization of neural networks dedicated to the production of speech during healthy aging. (C) 2009 Elsevier Inc. All rights reserved.

【 授权许可】

Free