The relationships between age, associative memory performance, and the neural correlates of successful associative memory encoding

NEUROBIOLOGY OF AGING

卷:42

Article

de Chastelaine, Marianne^1,2  Mattson, Julia T.³  Wang, Tracy H.^1,2  Donley, Brian E.^1,2  Rugg, Michael D.^1,2 

[1] Univ Texas Dallas, Ctr Vital Longev, 1600 Viceroy Dr,Suite 800, Dallas, TX 75235 USA

[2] Univ Texas Dallas, Sch Behav & Brain Sci, 1600 Viceroy Dr,Suite 800, Dallas, TX 75235 USA

[3] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA

关键词: fMRI;    Aging;    Associative recognition;    Episodic memory;    Hippocampus;    Over-recruitment;   

DOI  :  10.1016/j.neurobiolaging.2016.03.015

来源: Elsevier

【 摘 要 】

Using functional magnetic resonance imaging, subsequent memory effects (greater activity for later remembered than later forgotten study items) predictive of associative encoding were compared across samples of young, middle-aged, and older adults (total N = 136). During scanning, participants studied visually presented word pairs. In a later test phase, they discriminated between studied pairs, rearranged pairs (items studied on different trials), and new pairs. Subsequent memory effects were identified by contrasting activity elicited by study pairs that went on to be correctly judged intact or incorrectly judged rearranged. Effects in the hippocampus were age-invariant and positively correlated across participants with associative memory performance. Subsequent memory effects in the right inferior frontal gyrus (IFG) were greater in the older than the young group. In older participants only, both left and, in contrast to prior reports, right IFG subsequent memory effects correlated positively with memory performance. We suggest that the IFG is especially vulnerable to age-related decline in functional integrity and that the relationship between encoding-related activity in right IFG and memory performance depends on the experimental context. (C) 2016 Elsevier Inc. All rights reserved.

【 授权许可】

Free