Levodopa improves response inhibition and enhances striatal activation in early-stage Parkinson's disease

NEUROBIOLOGY OF AGING

卷:66

Article

Manza, Peter¹  Schwartz, Guy²  Masson, Mala¹  Kann, Sarah¹  Volkow, Nora D.^3,4  Li, Chiang-shan R.^5,6,7,8  Leung, Hoi-Chung¹ 

[1] SUNY Stony Brook, Dept Psychol, Integrat Neurosci Program, Stony Brook, NY 11794 USA

[2] SUNY Stony Brook, Dept Neurol, Stony Brook, NY 11794 USA

[3] NIAAA, NIH, Bethesda, MD USA

[4] NIDA, NIH, Bethesda, MD 20892 USA

[5] Yale Univ, Dept Psychiat, New Haven, CT 06520 USA

[6] Yale Univ, Dept Neurosci, New Haven, CT USA

[7] Yale Univ, Interdept Neurosci Program, New Haven, CT USA

[8] Beijing Huilongguan Hosp, Beijing, Peoples R China

关键词: Cognitive control;    Executive function;    Dopamine;    Stop-signal task;    Movement disorders;    Basal ganglia;   

DOI  :  10.1016/j.neurobiolaging.2018.02.003

来源: Elsevier

【 摘 要 】

Dopaminergic medications improve the motor symptoms of Parkinson's disease (PD), but their effect on response inhibition, a critical executive function, remains unclear. Previous studies primarily enrolled patients in more advanced stages of PD, when dopaminergic medication loses efficacy, and patients were typically on multiple medications. Here, we recruited 21 patients in early-stage PD on levodopa monotherapy and 37 age-matched controls to perform the stop-signal task during functional magnetic resonance imaging. In contrast to previous studies reporting null effects in more advanced PD, levodopa significantly improved response inhibition performance in our sample. No significant group differences were found in brain activations to pure motor inhibition or error processing (stop success vs. error trials). However, relative to controls, the PD group showed weaker striatal activations to salient events (infrequent vs. frequent events: stop vs. go trials) and fronto-striatal task-residual functional connectivity; both were restored with levodopa. Thus, levodopa appears to improve an important executive function in early-stage PD via enhanced salient signal processing, shedding new light on the role of dopaminergic signaling in response inhibition. Published by Elsevier Inc.

【 授权许可】

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