White matter integrity as a marker for cognitive plasticity in aging

NEUROBIOLOGY OF AGING

卷:47

Article

de Lange, Ann-Marie Glaso¹  Brathen, Anne Cecilie Sjoli¹  Grydeland, Hakon¹  Sexton, Claire³  Johansen-Berg, Heidi³  Andersson, Jesper L. R.³  Rohani, Darius A.¹  Nyberg, Lars⁴  Fjell, Anders M.^1,2  Walhovd, Kristine B.^1,2 

[1] Univ Oslo, Dept Psychol, Res Grp Lifespan Changes Brain & Cognit, Oslo, Norway

[2] Oslo Univ Hosp, Dept Phys Med & Rehabil, Unit Neuropsychol, Oslo, Norway

[3] Univ Oxford, Nuffield Dept Clin Neurosci, Oxford Ctr Funct Magnet Resonance Imaging Brain, FMRIB Ctr, Oxford, England

[4] Umea Univ, Umea Ctr Funct Brain Imaging, Umea, Sweden

关键词: Cognitive training;    Plasticity;    Aging;    White matter;    Diffusion tensor imaging;    Memory;   

DOI  :  10.1016/j.neurobiolaging.2016.07.007

来源: Elsevier

【 摘 要 】

Age-related differences in white matter (WM) integrity are substantial, but it is unknown whether between subject variability in WM integrity influences the capacity for cognitive improvement. We investigated the effects of memory training related to active and passive control conditions in older adults and tested whether WM integrity at baseline was predictive of training benefits. We hypothesized that (1) memory improvement would be restricted to the training group, (2) widespread areas would show greater mean diffusivity (MD) and lower fractional anisotropy in older adults relative to young adults, and (3) within these areas, variability in WM microstructure in the older group would be predictive of training gains. The results showed that only the group receiving training improved their memory. Significant age differences in MD and fractional anisotropy were found in widespread areas. Within these areas, voxelwise analyses showed a negative relationship between MD and memory improvement in 3 clusters, indicating that WM integrity could serve as a marker for the ability to adapt in response to cognitive challenges in aging. (C) 2016 The Authors. Published by Elsevier Inc.

【 授权许可】

Free