CSF neurofilament light levels predict hippocampal atrophy in cognitively healthy older adults

NEUROBIOLOGY OF AGING

卷:49

Article

Idland, Ane-Victoria^1,2  Sala-Llonch, Roser²  Borza, Tom³  Watne, Leiv Otto^1,4  Wyller, Torgeir Bruun^1,5  Braekhus, Anne^5,6,7  Zetterberg, Henrik^8,9  Blennow, Kaj⁸  Walhovd, Kristine Beate²  Fjell, Anders Martin² 

[1] Univ Oslo, Oslo Delirium Res Grp, Dept Geriatr Med, Inst Clin Med, Oslo, Norway

[2] Univ Oslo, Res Grp Lifespan Changes Brain & Cognit, Dept Psychol, Oslo, Norway

[3] Innlandet Hosp Trust, Ctr Old Age Psychiat Res, Ottestad, Norway

[4] Univ Oslo, Inst Basic Med Sci, Oslo, Norway

[5] Oslo Univ Hosp, Dept Geriatr Med, Oslo, Norway

[6] Vestfold Hosp Trust, Norwegian Natl Advisory Unit Ageing & Hlth, Tonsberg, Norway

[7] Oslo Univ Hosp, Dept Neurol, Oslo, Norway

[8] Univ Gothenburg, Dept Psychiat & Neurochem, Clin Neurochem Lab, Inst Neurosci & Physiol,Sahlgrenska Acad, Gothenburg, Sweden

[9] UCL Inst Neurol, Dept Mol Neurosci, London, England

关键词: Cerebrospinal fluid;    Magnetic resonance imaging;    Normal aging;    Neurofilament light;    Hippocampal atrophy rate;   

DOI  :  10.1016/j.neurobiolaging.2016.09.012

来源: Elsevier

【 摘 要 】

Cerebrospinal fluid (CSF) neurofilament light (NFL) is a marker of axonal degeneration. We tested whether CSF NFL levels predict hippocampal atrophy rate in cognitively healthy older adults independently of the established CSF Alzheimer's disease (AD) biomarkers, b-amyloid 1-42, and phosphorylated tau (P-tau). We included 144 participants in a 2-year longitudinal study with baseline CSF measures and 2 magnetic resonance images. Eighty-eight participants had full data available. A subgroup of 36 participants with very low AD risk was also studied. NFL predicted hippocampal atrophy rate independently of age, b-amyloid 1-42, and P-tau. Including NFL, P-tau, and age in the same model, higher NFL and lower P-tau predicted higher hippocampal atrophy (R-2 = 0.20, NFL: beta = - 0.34; p = 0.003; P-tau: beta - 0.27; p 0.009). The results were upheld in the participants with very low AD risk. NFL predicted neurodegeneration in older adults with very low AD probability. We suggest that factors previously shown to be important for brain degeneration in mild cognitive impairment may also impact changes in normal aging, demonstrating that NFL is likely to indicate AD-independent, age-expected neurodegeneration. (C) 2016 Elsevier Inc. All rights reserved.

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