DECREASED NUMBER OF VASOPRESSIN IMMUNOREACTIVE NEURONS IN THE MEDIAL AMYGDALA AND LOCUS-CERULEUS OF THE AGED RAT

NEUROBIOLOGY OF AGING

卷:14

Article

关键词: VASOPRESSIN;    IMMUNOCYTOCHEMISTRY;    AGING;    CELL NUMBER;    BED NUCLEUS OF THE STRIA TERMINALIS MEDIALIS;    MEDIAL AMYGDALA;    LOCUS-CERULEUS;    SUBCOERULEUS;   

DOI  :  10.1016/0197-4580(93)90008-Y

来源: Elsevier

【 摘 要 】

The earlier described age-related decreases in vasopressin innervation of extra-hypothalamic rat brain regions were found to coincide with a decrease in vasopressin expression in the cells where these fibers originated. A significant age-related decrease in the number of vasopressin-immunoreactive cell bodies was found in the medial amygdala and locus coeruleus of senescent Brown-Norway (BN/BiRij) rats (33 months) when compared to middle-aged (19 months) and young (3 months) rats. In addition, total testosterone plasma levels were significantly reduced in middle-aged and old rats as compared to young animals and the number of vasopressin-immunoreactive cells in both the medial amygdala and locus coeruleus correlated significantly with the decreased testosterone levels in a similar way as found earlier for vasopressin terminals.

【 授权许可】

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