Brain regional lesion burden and impaired mobility in the elderly

NEUROBIOLOGY OF AGING

卷:32

Article

Moscufo, Nicola^1,3  Guttmann, Charles R. G.^1,2  Meier, Dominik¹  Csapo, Istvan¹  Hildenbrand, Peter G.^1,4  Healy, Brian C.²  Schmidt, Julia A.³  Wolfson, Leslie³ 

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Ctr Neurol Imaging,Dept Radiol, Boston, MA 02115 USA

[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Neurol, Boston, MA 02115 USA

[3] Univ Connecticut, Ctr Hlth, Dept Neurol, Farmington, CT 06030 USA

[4] Lahey Clin Fdn, Burlington, MA 01805 USA

关键词: Aging;    Mobility;    Brain;    White matter;    White matter hyperintensity;    Splenium of corpus callosum;    Corona radiata;    Magnetic resonance imaging;   

DOI  :  10.1016/j.neurobiolaging.2009.04.010

来源: Elsevier

【 摘 要 】

This study investigated the relationship of brain white matter (WM) lesions affecting specific neural networks with decreased mobility in ninety-nine healthy community-dwelling subjects >= 75 years old prospectively enrolled by age and mobility status. We assessed lesion burden in the genu, body and splenium of corpus callosum; anterior, superior and posterior corona radiata; anterior and posterior limbs of internal capsule; corticospinal tract; and superior longitudinal fasciculus. Burden in the splenium of corpus callosum (SCC) demonstrated the highest correlation particularly with walking speed (r=0.4, p < 10(-4)), and in logistic regression it was the best regional predictor of low mobility performance. We also found that independent of mobility, corona radiata has the largest lesion burden with anterior (ACR) and posterior (PCR) aspects being the most frequently affected. The results suggest that compromised inter-hemispheric integration of visuospatial information through the SCC plays an important role in mobility impairment in the elderly. The relatively high lesion susceptibility of ACR and PCR in all subjects may obscure the importance of these lesions in mobility impairment. (C) 2009 Elsevier Inc. All rights reserved.

【 授权许可】

Free