Delineating the topography of amyloid-associated cortical atrophy in Down syndrome

NEUROBIOLOGY OF AGING

卷:80

Article

Mak, Elijah¹  Padilla, Concepcion¹  Annus, Tiina¹  Wilson, Liam R.¹  Hong, Young T.²  Fryer, Tim D.²  Coles, Jonathan P.³  Aigbirhio, Franklin, I²  Menon, David K.³  Nestor, Peter J.⁴  Zaman, Shahid H.¹  Holland, Anthony J.¹ 

[1] Univ Cambridge, Dept Psychiat, Douglas House,18B Trumpington Rd, Cambridge CB2 8AH, England

[2] Wolfson Brain Imaging Ctr, Dept Clin Neurosci, Cambridge, England

[3] Univ Cambridge, Div Anaesthesia, Cambridge, England

[4] Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia

关键词: Down syndrome;    Alzheimer's disease;    Dementia;    Amyloid;    PET;    MRI;    Atrophy;   

DOI  :  10.1016/j.neurobiolaging.2019.02.018

来源: Elsevier

【 摘 要 】

Older adults with Down syndrome (DS) often have Alzheimer's disease (AD) neuropathologies. Although positron emission tomography imaging studies of amyloid deposition (beta amyloid, A beta) have been associated with worse clinical prognosis and cognitive impairment, their relationships with cortical thickness remain unclear in people with DS. In a sample of 44 DS adults who underwent cognitive assessments, [C-11]-PiB positron emission tomography, and T1-weighted magnetization-prepared rapid gradient echo, we used mixed effect models to evaluate the spatial relationships between A beta binding with patterns of cortical thickness. Partial Spearman correlations were used to delineate the topography of local A beta-associated cortical thinning. [C-11]-PiB nondisplaceable binding potential was negatively associated with decreased cortical thickness. Locally, regional [C-11]-PiB retention was negatively correlated with cortical thickness in widespread cortices, predominantly in temporoparietal regions. Contrary to the prevailing evidence in established AD, we propose that our findings implicate A beta in spatial patterns of atrophy that recapitulated the cortical signature of neurodegeneration in AD, conferring support to recent recommendations for earlier disease-interventions. (C) 2019 Elsevier Inc. All rights reserved.

【 授权许可】

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