Molecular imaging of beta-amyloid deposition in late-life depression

NEUROBIOLOGY OF AGING

卷:101

Article

Smith, Gwenn S.^1,2  Kuwabara, Hiroto²  Nandi, Ayon²  Gould, Neda F.¹  Nassery, Najilla³  Savonenko, Alena⁴  Joo, Jin Hui¹  Kraut, Michael⁵  Brasic, James²  Holt, Daniel P.²  Hall, Andrew W.²  Mathews, William B.²  Dannals, Robert F.²  Avramopoulos, Dimitrios⁶  Workman, Clifford I.¹ 

[1] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Div Geriatr Psychiat & Neuropsychiat, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Div Nucl Med & Mol Imaging, Baltimore, MD USA

[3] Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD USA

[4] Johns Hopkins Univ, Sch Med, Dept Pathol Neuropathol, Baltimore, MD USA

[5] Johns Hopkins Univ, Sch Med, Dept Med, Div Gen Internal Med, Baltimore, MD 21205 USA

[6] Johns Hopkins Univ, Sch Med, Dept Med Genet, Baltimore, MD USA

关键词: Beta-amyloid;    Positron emission tomography;    Late-Life;    Depression;    Aging;    Selective serotonin reuptake inhibitors;    Citalopram;    Sertraline;   

DOI  :  10.1016/j.neurobiolaging.2021.01.002

来源: Elsevier

【 摘 要 】

Late-life depression (LLD) is associated with an increased risk of all-cause dementia and may involve Alzheimer's disease pathology. Twenty-one LLD patients who met the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, criteria for a current major depressive episode and 21 healthy controls underwent clinical and neuropsychological assessments, magnetic resonance imaging to measure gray matter volumes, and high-resolution positron emission tomography to measure beta-amyloid (A beta) deposition. Clinical and neuropsychological assessments were repeated after 10-12 weeks of Citalopram or Sertraline treatment (LLD patients only). LLD patients did not differ from healthy controls in baseline neuropsychological function, although patients improved in both depressive symptoms and visual-spatial memory during treatment. Greater A beta in the left parietal cortex was observed in LLD patients compared with controls. Greater A beta was correlated with greater depressive symptoms and poorer visual-spatial memory, but not with improvement with treatment. The study of LLD patients with prospective measurements of mood and cognitive responses to antidepressant treatment is an opportunity to understand early neurobiological mechanisms underlying the association between depression and subsequent cognitive decline. (C) 2021 Published by Elsevier Inc.

【 授权许可】

Free