Disappearing metabolic youthfulness in the cognitively impaired female brain

NEUROBIOLOGY OF AGING

卷:101

Article

Beheshti, Iman¹  Nugent, Scott¹  Potvin, Olivier¹  Duchesne, Simon^1,2 

[1] Quebec Mental Hlth Inst, CERVO Brain Res Ctr, Quebec City, PQ, Canada

[2] Univ Laval, Fac Med, Radiol & Nucl Med Dept, Quebec City, PQ, Canada

关键词: Alzheimer’ s disease;    Mild cognitive impairment;    Metabolic brain-age;    Fluorodeoxyglucose;    Positron emission tomography;    Sex difference;   

DOI  :  10.1016/j.neurobiolaging.2021.01.026

来源: Elsevier

【 摘 要 】

Sex differences play a vital role in human brain structure and physiology. Previous reports have proposed evidence hinting at a metabolic advantage in female brains across adulthood. It remained to be determined whether this advantage would be maintained across the spectrum of cognitive impairment, up to and including dementia due to Alzheimer's disease (AD). Here, using a machine-learning algorithm, we explore sex differences in metabolic brain-age derived from fluorodeoxyglucose positron emission tomography imaging among cognitively healthy individuals and those affected by mild cognitive impairment and clinically probable AD. First, we report that cognitively healthy male participants showed a persistently older looking brains when compared to healthy female participants in term of metabolic brain age, confirming earlier reports. However, this distinction disappeared among MCI individuals and probable AD patients, and this loss could not be explained by an accompanying neurodegeneration. This would seem to indicate that females have a higher rate of decline in brain glucose metabolism when cognitively impaired to negate their prior advantage. (c) 2021 Elsevier Inc. All rights reserved.

【 授权许可】

Free