Benefit of interleaved practice of motor skills is associated with changes in functional brain network topology that differ between younger and older adults

NEUROBIOLOGY OF AGING

卷:42

Article

Lin, Chien-Ho (Janice)^1,2  Knowlton, Barbara J.³  Wu, Allan D.^4,5  Iacoboni, Marco^5,6  Yang, Ho-Ching⁷  Ye, Yu-Ling^7,8  Liu, Kuan-Hong⁷  Chiang, Ming-Chang⁷ 

[1] Natl Yang Ming Univ, Dept Phys Therapy & Assist Technol, Taipei 112, Taiwan

[2] Yeong An Orthoped & Phys Therapy Clin, Taipei, Taiwan

[3] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA USA

[4] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA

[5] Univ Calif Los Angeles, Ahmanson Lovelace Brain Mapping Ctr, Los Angeles, CA USA

[6] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA

[7] Natl Yang Ming Univ, Dept Biomed Engn, 155,Sec 2,Linong St, Taipei 112, Taiwan

[8] Chang Gung Mem Hosp, Dept Diagnost Radiol, Chiayi, Taiwan

关键词: Contextual interference;    Serial reaction time task;    Psychophysiological interaction;    Functional connectivity;    Small-world networks;    Functional magnetic resonance imaging;   

DOI  :  10.1016/j.neurobiolaging.2016.03.010

来源: Elsevier

【 摘 要 】

Practicing tasks arranged in an interleaved manner generally leads to superior retention compared with practicing tasks repetitively, a phenomenon known as the contextual interference (CI) effect. We investigated the brain network of motor learning under CI, that is, the CI network, and how it was affected by aging. Sixteen younger and 16 older adults practiced motor sequences arranged in a repetitive or an interleaved order over 2 days, followed by a retention test on day 5 to evaluate learning. Network analysis was applied to functional MRI data on retention to define the CI network by identifying brain regions with greater between region connectivity after interleaved compared with repetitive practice. CI effects were present in both groups but stronger in younger adults. Moreover, CI networks in younger adults exhibited efficient small world topology, with a significant association between higher network centrality and better learning after interleaved practice. Older adults did not show such favorable network properties. Our findings suggest that aging affects the efficiency of brain networks underlying enhanced motor learning after CI practice. (C) 2016 Elsevier Inc. All rights reserved.

【 授权许可】

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