Increased cerebral blood volume in small arterial vessels is a correlate of amyloid-β-related cognitive decline

NEUROBIOLOGY OF AGING

卷:76

Article

Hua, Jun^1,2  Lee, SeungWook³  Blair, Nicholas I. S.³  Wyss, Michael^4,5  van Bergen, Jiri M. G.⁶  Schreiner, Simon J.^6,7  Kagerer, Sonja M.^6,7  Leh, Sandra E.⁶  Gietl, Anton E.⁶  Treyer, Valerie^6,8  Buck, Alfred⁸  Nitsch, Roger M.⁶  Pruessmann, Klaas P.^4,5  Lu, Hanzhang^1,2  Van Zijl, Peter C. M.^1,2  Albert, Marilyn⁹  Hock, Christoph⁶  Unschuld, Paul G.^6,7 

[1] Johns Hopkins Univ, Sch Med, Dept Radiol, Neurosect,Div MRI Res, Baltimore, MD 21205 USA

[2] Kennedy Krieger Inst, FM Kirby Res Ctr Funct Brain Imaging, Baltimore, MD USA

[3] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD USA

[4] Univ Zurich, Inst Biomed Engn, Zurich, Switzerland

[5] Swiss Fed Inst Technol, Zurich, Switzerland

[6] Univ Zurich, Inst Regenerat Med IREM, Schlieren, Switzerland

[7] Psychiat Univ Hosp Zurich PUK, Hosp Psychogeriatr Med, Zurich, Switzerland

[8] Univ Hosp Zurich, Dept Nucl Med, Zurich, Switzerland

[9] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

关键词: MRI;    PET;    CBV;    7 Tesla;    Imaging;    Biomarker;    Vascular;    Perfusion;    High field;    Aging;    Cerebral autoregulation;    Alzheimer's disease;   

DOI  :  10.1016/j.neurobiolaging.2019.01.001

来源: Elsevier

【 摘 要 】

The protracted accumulation of amyloid-beta (A beta) is a major pathologic hallmark of Alzheimer's disease and may trigger secondary pathological processes that include neurovascular damage. This study was aimed at investigating long-term effects of A beta burden on cerebral blood volume of arterioles and pial arteries (CBVa), possibly present before manifestation of dementia. A beta burden was assessed by 11C Pittsburgh compound-B positron emission tomography in 22 controls and 18 persons with mild cognitive impairment (MCI), [ages: 75(+/-6) years]. After 2 years, inflow-based vascular space occupancy at ultra-high field strength of 7-Tesla was administered for measuring CBVa, and neuropsychological testing for cognitive decline. Crushing gradients were incorporated during MR-imaging to suppress signals from fast-flowing blood in large arteries, and thereby sensitize inflow-based vascular space occupancy to CBVa in pial arteries and arterioles. CBVa was significantly elevated in MCI compared to cognitively normal controls and regional CBVa related to local A beta deposition. For both MCI and controls, A beta burden and follow-up CBVa in several brain regions synergistically predicted cognitive decline over 2 years. Orbitofrontal CBVa was positively associated with apolipoprotein E e4 carrier status. Increased CBVa may reflect long-term effects of region-specific pathology associated with A beta deposition. Additional studies are needed to clarify the role of the arteriolar system and the potential of CBVa as a biomarker for A beta-related vascular downstream pathology. (C) 2019 The Authors. Published by Elsevier Inc.

【 授权许可】

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