In vitro maturation improves oocyte or embryo cryopreservation outcome in breast cancer patients undergoing ovarian stimulation for fertility preservation

REPRODUCTIVE BIOMEDICINE ONLINE

卷:20

Article

Oktay, K.^1,2,3  Buyuk, E.^4,5  Rodriguez-Wallberg, K. A.^1,2,3,6,7  Sahin, G.^1,2,3 

[1] New York Med Coll, Inst Fertil Preservat, Valhalla, NY 10595 USA

[2] New York Med Coll, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, Valhalla, NY 10595 USA

[3] Westchester Med Ctr, Valhalla, NY 10595 USA

[4] Albert Einstein Coll Med, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, Hartsdale, NY 10530 USA

[5] Inst Reprod Med & Hlth, Hartsdale, NY 10530 USA

[6] Karolinska Inst, Stockholm, Sweden

[7] Karolinska Univ Hosp, Stockholm, Sweden

关键词: cryopreservation;    embryo;    fertility preservation;    in-vitro maturation;    oocyte;   

DOI  :  10.1016/j.rbmo.2010.01.012

来源: Elsevier

【 摘 要 】

This study tested in-vitro maturation (IVM) as a complementary strategy to improve the mature oocyte yield of breast cancer patients undergoing ovarian stimulation for fertility preservation. Secondary analysis of prospectively collected data is performed for 32 breast cancer patients undergoing oocyte or embryo cryopreservation before chemotherapy. Total number of oocytes and/or embryos cryopreserved following IVM is compared with the total number cryopreserved before IVM. Overall, 464 oocytes were retrieved, of which 274 were mature. Following IVM, the number of total mature oocytes increased to 399 (45% increase in mature oocyte yield, P < 0.0001). Fertilization rate after IVM was statistically significantly higher than the fertilization of already mature oocytes at retrieval (86% versus 73%, respectively, P < 0.05). The total number of oocytes and embryos frozen before IVM was 207 (45% of all oocytes retrieved). This number increased to 320 (69% of all oocytes retrieved) following IVM (P < 0.0001). IVM is a useful strategy to improve the mature oocyte yield of fertility preservation cycles. Immature oocytes retrieved during oocyte/embryo cryopreservation cycles should not be discarded to improve the future potential of fertility. (C) 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

Free