Is polycystic ovary syndrome a sexual conflict? A review

REPRODUCTIVE BIOMEDICINE ONLINE

卷:32

Review

Casarini, Livio^1,2  Simoni, Manuela^1,2,3  Brigante, Giulia^1,3 

[1] Univ Modena & Reggio Emilia, Dept Biomed Metab & Neural Sci, Unit Endocrinol, Modena, Italy

[2] Univ Modena & Reggio Emilia, Ctr Genom Res, Modena, Italy

[3] Azienda USL, Dept Med Endocrinol Metab & Geriatr, Modena, Italy

关键词: evolution;    gender;    hyperandrogenic;    metabolic;    PCOS;    sex-specific;   

DOI  :  10.1016/j.rbmo.2016.01.011

来源: Elsevier

【 摘 要 】

Several studies have attempted to explain the high overall prevalence of polycystic ovary syndrome among women worldwide (about 4-10%) despite its link to subfertile phenotypes. For this reason, it is considered an evolutionary paradox. In this review, we show that several genetic loci associated with the disease differently modulate the reproductive parameters of men and women. This observation suggests that such genetic variants lead to opposite effects in the two sexes in reproductive success. Intralocus sexual conflict as a cause of the persistence polycystic ovary syndrome genotypes among humans is supported. (C) 2016 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

Free