Recurrent implantation failure in assisted reproduction: how to counsel and manage. A. General considerations and treatment options that may benefit the couple

REPRODUCTIVE BIOMEDICINE ONLINE

卷:11

Review

Urman, B ; Yakin, K ; Balaban, B

关键词: assisted reproduction;    embryo transfer;    endometriosis;    fibroids;    hysteroscopy;    implantation failure;   

DOI  :  10.1016/S1472-6483(10)60846-2

来源: Elsevier

【 摘 要 】

Recurrent implantation failure is a distressing phenomenon, both for the infertile couple and for the physician responsible for their treatment. Aetiology is often not clear and treatment options are vague. Particulary when transferred embryos are of good quality, recurrnt implantation failure may be attributed to less than optimal embryo transfer technique, pathological lesions of the uterine cavity, the presence of hydrosal pinges, fibroids and endometriosis. Poor embryo quality, espically when repetitive, is a major impediment to successful implantation and cannot be corrected at the present time. Molecular abnormalities at the andometrial level and abnormal embryo-endometrium dialogue may be responsible for some cases of recurrent implantation failure. Futhermore, there may be over- or under-expressed genes that may be related to successful implantantion. At the present time, the physician confronted with a couple presenting with recurrent implantation failure should discuss openly the potential causes of this phenomenon with special emphasis on correctable causes, and offer remedies that are evidence based.

【 授权许可】

Free