Randomized controlled pilot trial of luteal phase recombinant FSH stimulation in poor responders

REPRODUCTIVE BIOMEDICINE ONLINE

卷:17

Article

Kalra, Suleena Kansal¹  Ratcliffe, Sarah²  Gracia, Clarisa R.¹  Martino, Linda¹  Coutifaris, Christos¹  Barnhart, Kurt T.¹ 

[1] Hosp Univ Penn, Dept Obstet & Gynecol, Div Reprod Endorcinol & Infertil, Philadelphia, PA 19104 USA

[2] Hosp Univ Penn, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA

关键词: FSH;    GnRH antagonist;    IVF;    luteal phase;    poor ovarian response;    recombinant FSH;   

DOI  :  10.1016/S1472-6483(10)60400-2

来源: Elsevier

【 摘 要 】

This Study investigated whether luteal phase initiation of FSH Supplementation would improve oocyte yield compared with follicular phase administration in women with poor ovarian response (POR). A two-arm, randomized, open-label pilot trial was performed at a university-based infertility centre. In nine of 18 infertile women with a history of POR ill a previous cycle [< 5 follicles on clay of human chorionic gonadotrophin (HCG) administration; < 5 oocytes retrieved; previous IVF cycle cancellation due to POR] FSH was administered during the mid-luteal phase of the preceding menstrual cycle. The primary outcome measure was the number of oocytes retrieved. Secondary endpoints included: follicles > 10 mill and > 16 mm and oestradiol concentration oil the day of HCG administration, peak oestrogen concentration, pregnancy and live birth rates. All endpoints comparing luteal versus follicular stimulation were similar. In paired analysis of patients in the luteal arm compared with the prior cycle, there was a significant increase ill days of stimulation (P = 0.01) and number of follicles > 10 mm (P = 0.02) and > 1 6 mm (P = 0.02) oil day of HCG administration. IVF outcomes with luteal phase FSH compared with follicular phase FSH were similar. Luteal phase initiation of FSH is a safe and potential alternative protocol in poor responders.

【 授权许可】

Free