Ovarian stimulation leads to a severe implantation defect in mice

REPRODUCTIVE BIOMEDICINE ONLINE

卷:27

Article

Deng, Shaorong¹  Xu, Jing¹  Zeng, Jianwu¹  Hu, Linli²  Wu, Yunxia¹ 

[1] Tongji Sch Pharm, Dept Chinese Herbs, Wuhan 430030, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Ctr Reprod Med, Affiliated Tongji Hosp, Wuhan 430030, Peoples R China

关键词: corpus luteum;    decidua;    embryo;    implantation dysfunction;    mouse;    ovarian stimulation;   

DOI  :  10.1016/j.rbmo.2013.03.018

来源: Elsevier

【 摘 要 】

The aim of the present study was to evaluate whether ovarian stimulation could induce embryo implantation dysfunction in mice and to explore the possible mechanisms involved. Ovarian stimulation was performed with intraperitoneal injections of 0, 2.5, 5.0, 7.5 and 10.0 IU pregnant mare serum gonadotrophin followed by the same dose of human chorionic gonadotrophin 48 h later. A dose-dependent implantation defect in stimulated mice was demonstrated, which can be mainly explained by premature luteolysis and secondary endometrial changes induced by an imbalance in oestradiol and progesterone. RBMOnline (C) 2013, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

Free