Endometrial thickness as a predictor of pregnancy outcomes in 10787 fresh IVF-ICSI cycles

REPRODUCTIVE BIOMEDICINE ONLINE

卷:33

Article

Yuan, Xi^1,2,3  Saravelos, Sotirios H.²  Wang, Qiong¹  Xu, Yanwen¹  Li, Tin-Chiu²  Zhou, Canquan¹ 

[1] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Obstetr & Gynecol, Reprod Med Ctr, Guangzhou, Guangdong, Peoples R China

[2] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Obstet & Gynecol, Hong Kong, Hong Kong, Peoples R China

[3] MOH Holdings Pte Ltd MOHH, Singapore, Singapore

关键词: clinical outcome;    endometrial thickness;    endometrium;    IVF-ICSI;   

DOI  :  10.1016/j.rbmo.2016.05.002

来源: Elsevier

【 摘 要 】

This retrospective study assessed the predictive value of endometrial thickness (EMT) on HCG administration day for the clinical outcome of fresh IVF and intracytoplasmic sperm injection (ICSI) cycles. A total of 8690 consecutive women undergoing 10,787 cycles over a 5-year period were included. The 5th, 50th and 95th centiles for EMT were determined as 8, 11 and 15 mm, respectively. Group analysis according to these centiles (Group 1: < 8 mm; Group 2: >= 8 and <= 11 mm; Group 3: > 11 and <= 15 mm; Group 4: > 15 mm) demonstrated significant differences (P < 0.001) in clinical pregnancy rates (23.0%, 37.2%, 46.2% and 53.3%, respectively), live birth rates per clinical pregnancy (63.3%, 72.0%, 78.1% and 80.3%, respectively), spontaneous abortion rates (26.7%, 23.8%, 19.9% and 17.5%, respectively), and ectopic pregnancy rates (10.0%, 4.3%, 2.1% and 2.2%, respectively). Logistic regression analyses showed EMT as one of the independent variables predictive of clinical pregnancy (OR = 1.097; P < 0.001), live birth (OR = 1.078; P < 0.001), spontaneous abortion (OR = 0.948; P < 0.001), and ectopic pregnancy (OR = 0.851; P < 0.001). Future research should aim to understand the underlying mechanisms relating EMT to conception, ectopic implantation and spontaneous abortion. (C) 2016 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

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