GnRH antagonist pre-treatment: one centre's experience for IVF-ICSI cycle scheduling

REPRODUCTIVE BIOMEDICINE ONLINE

卷:30

Article

Viardot-Foucault, Veronique¹  Nadarajah, Sadhana¹  Lye, Weng Kit²  Tan, Heng Hao¹ 

[1] KK Womens & Childrens Hosp, Dept Reprod Med, Singapore 229899, Singapore

[2] Duke NUS Grad Med Sch, Off Clin Sci, Ctr Quantitat Med, Singapore 169857, Singapore

关键词: cycle scheduling;    gonadotropin-releasing hormone antagonist;    in-vitro fertilization;    programming;   

DOI  :  10.1016/j.rbmo.2014.11.018

来源: Elsevier

【 摘 要 】

Scheduling gonadotrophin-releasing hormone antagonist (GnRH-ant) cycles for IVF intracytoplasmic sperm injection in patients is a challenge because of unpredictable ovum retrieval procedures on weekends, when less manpower is available. Recently, the use of GnRH-ant pre-treatment to delay an IVF and intracytoplasmic sperm injection (ICSI) cycle showed no negative effect on clinical pregnancy rates. An age-matched, case-control study was conducted to evaluate the effectiveness of such pre-treatment for scheduling purposes. Patients (n = 140) undergoing their first ovarian stimulation for IVF-ICSI were included. Patients starting their stimulation on Tuesdays or Wednesdays were most likely to have their ovum retrieval procedure on Saturdays. Seventy patients received a 3-day course of GnRH-ant before starting stimulation, and were compared with 70 age-matched controls not receiving pre-treatment. The main outcomes were the proportion of ovum retrieval procedures occurring on Saturdays, clinical pregnancy rate and live birth rates. A five-fold reduction in the number of ovum retrievals occurred on Saturdays compared with controls (7.1% versus 34.3%; OR 0.15; 95% CI 0.05 to 0.42; P < 0.001), with no significant differences in clinical pregnancy rate (40.9% versus 37.5%) and live birth rate (27.3% versus 31.3%). GnRH-ant pre-treatment is an effective tool for scheduling of GnRH-ant cycles. (C) 2014 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

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