Long-term duration of function of ovarian tissue transplants: case reports

REPRODUCTIVE BIOMEDICINE ONLINE

卷:25

Review

Andersen, Claus Yding²  Silber, Sherman J.¹  Berghold, Stinne Holm³  Jorgensen, Jan Stener⁴  Ernst, Erik⁵ 

[1] St Lukes Hosp, Infertil Ctr St Louis, St Louis, MO 63017 USA

[2] Univ Copenhagen, Fac Hlth Sci, Univ Hosp Copenhagen, Lab Reprod Biol,Juliane Marie Ctr Women Children, Copenhagen, Denmark

[3] Univ So Denmark, Res Unit Gen Practice, Odense, Denmark

[4] Odense Univ, Dept Ghynecol & Obstet, Odense, Denmark

[5] Aarhus Univ Hosp, Dept Gynecol & Obstet, DK-8000 Aarhus, Denmark

关键词: cryopreservation;    fertility preservation;    ovarian failure;    ovary;    transplantation;   

DOI  :  10.1016/j.rbmo.2012.03.014

来源: Elsevier

【 摘 要 】

These three case reports describe the long-term duration of function of ovarian cortical tissue grafts among patients in a university fertility preservation programme in Europe and in a private practice programme in the USA. One woman underwent sterilizing cancer treatment and had frozen ovarian tissue transplanted, and two women underwent fresh ovarian tissue transplants. The function of ovarian cortical strips has continued for more than 7 years in these three women, with the birth of eight healthy babies following a single graft per patient. In addition to these three cases, transplantation ( repeatedly in some cases) of cryopreserved ovarian tissue has restored reproductive function to all other women in the study centres' programmes for some years. The sustained longevity of function of the transplanted tissue suggests that it may also be possible to postpone the normal time of menopause or to alleviate its symptoms. RBMOnline (c) 2012, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

Free