Temperature gradients in female reproductive tissues

REPRODUCTIVE BIOMEDICINE ONLINE

卷:24

Review

Hunter, R. H. F.¹ 

[1] Univ Cambridge, Sidney Sussex Coll, Cambridge CB2 1TN, England

关键词: embryo;    fertilization;    gametes;    gene expression;    oviduct;   

DOI  :  10.1016/j.rbmo.2011.12.007

来源: Elsevier

【 摘 要 】

Deep body temperature in mammals is generally but incorrectly regarded as uniform. Alterations of temperature in oviducts and preovulatory Graafian follicles may play a vital role in gamete maturation, fertilization and early embryonic development. At a molecular level, the conformation of regulatory proteins is susceptible to changes in temperature. Deviation from physiological temperature during IVF procedures could thereby exert a profound influence on patterns of gene expression as the embryonic genome unfolds during early cleavage stages and act to generate specific anomalies. Systematic studies are urgently required. (C) 2012, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

Free