Views of internists towards uses of PGD

REPRODUCTIVE BIOMEDICINE ONLINE

卷:26

Article

Klitzman, Robert^1,4  Chung, Wendy¹  Marder, Karen¹  Shanmugham, Anita²  Chin, Lisa J.^1,3,4  Stark, Meredith¹  Leu, Cheng-Shiun¹  Appelbaum, Paul S.^1,4 

[1] Columbia Univ, New York, NY 10032 USA

[2] New York Presbyterian Morgan Stanley Childrens Ho, New York, NY USA

[3] New York State Psychiat Inst & Hosp, HIV Ctr Clin & Behav Studies, New York, NY 10032 USA

[4] Columbia Univ Coll Phys & Surg, New York State Psychiat Inst, New York, NY 10032 USA

关键词: assisted reproductive technology;    ethics;    IVF;    eugenics;    policy;    obstetrics;   

DOI  :  10.1016/j.rbmo.2012.11.006

来源: Elsevier

【 摘 要 】

Preimplantation genetic diagnosis (PGD) is increasingly available, but how physicians view it is unclear. Internists are gatekeepers and sources of information, often treating disorders for which PGD is possible. This quantitative study surveyed 220 US internists, who were found to be divided. Many would recommend PGD for cystic fibrosis (CF; 33.7%), breast cancer (BRCA; 23.4%), familial adenomatous polyposis (FAP; 20.6%) and familial hypertrophic cardiomyopathy (19.9%), but few for social sex selection (5.2%); however, in each case, >50% were unsure. Of those surveyed, 4.9% have suggested PGD to patients. Only 7.1% felt qualified to answer patient questions about it. Internists who would refer for PGD had completed medical training less recently and, for CF, were more likely to have privately insured patients (P < 0.033) and patients who reported genetic discrimination (P < 0.013). Physicians more likely to refer for BRCA and FAP were less likely to have patients ask about genetic testing. This study suggests that internists often feel they have insufficient knowledge about it and may refer for PGD based on limited understanding. They view possible uses of PGD differently, partly reflecting varying ages of onset and disease treatability. These data have critical implications for training, research and practice. RBMOnline (C) 2012, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

Free