Should we consider day-2 and day-3 embryo morphology before day-5 transfer when blastocysts reach a similar good quality?

REPRODUCTIVE BIOMEDICINE ONLINE

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Article

Herbemont, Charlene^1,2  Sarandi, Solmaz¹  Boujenah, Jeremy^2,3  Sermondade, Nathalie¹  Vivot, Alexandre⁵  Poncelet, Christophe^3,7  Grynberg, Michael^2,6,4,8  Sifer, Christophe^1,2 

[1] Hop Univ Paris Seine St Denis, AP HP, Dept Reprod Biol, F-93140 Bondy, France

[2] Univ Paris XIII, Sorbonne Paris Cite, UFR SMBH, F-9300 Bobigny, France

[3] Hop Univ Paris Seine St Denis, AP HP, Dept Obstet Gynecol & Reprod Med, F-93140 Bondy, France

[4] Hop Univ Paris Seine St Denis, AP HP, Dept Reprod Med, F-93140 Bondy, France

[5] Sorbonne Paris Cite, INSERM, UMR1153, Epidemiol & Stat,Team METHODS,Res Ctr CRESS, F-75004 Paris, France

[6] Paris Descartes Univ, F-75006 Paris, France

[7] Hop Hotel Dieu, AP HP, Ctr Epidemiol Clin, F-75004 Paris, France

[8] Univ Paris Diderot, INSERM, Unit U1133, F-75013 Paris, France

关键词: Cleavage stage embryo quality;    Extended culture;    Good-quality blastocyst;    Implantation rate;    Live birth rate;   

DOI  :  10.1016/j.rbmo.2017.07.014

来源: Elsevier

【 摘 要 】

Clinical outcomes of 291 day-5 blastocyst transfers carried out between January 2012 and March 2016 were retrospectively compared according to their quality at day 2 and 3. Inclusion criteria were female age younger than 37 years; first or second IVF and intracytoplasmic sperm injection cycle; quality of the transferred blastocyst: blastocoele B3 or higher; inner-cell-mass A/B; trophectoderm A/B; and known implantation outcome for each transferred blastocyst. Blastocysts were classified into good-quality and poor-quality embryo groups at day 2 and 3. Implantation (38.7% versus 41.4), clinical pregnancy (40.3% versus 45.9%), miscarriage (22.2% versus 26.7%;) and live birth rates (37.4% versus 38.8%) were comparable in day 2 good and poor-quality embryo groups. No signficiant differences in morphology of transferred blastocysts at day 3 were found. Multivariable analysis highlighted that poor or good embryo quality at day 2 and day 3 were not predictive of the implantation of good-quality blastocysts (at day 2: adjusted odds ratio = 0.82 CI 95% 0.49 to 1.38; at day 3: adjusted odds ratio = 1.39; CI 95% 0.77 to 2.52). Good-quality blastocyst transfer should, therefore, be carried out irrespective of embryo quality at cleavage stage, as it may not compromise success rates in a good-prognosis population. (C) 2017 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

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