Women's age and embryo developmental speed accurately predict clinical pregnancy after single vitrified-warmed blastocyst transfer

REPRODUCTIVE BIOMEDICINE ONLINE

卷:29

Article

Kato, Keiichi^1,2  Ueno, Satoshi¹  Yabuuchi, Akiko¹  Uchiyama, Kazuo¹  Okuno, Takashi¹  Kobayashi, Tamotsu¹  Segawa, Tomoya³  Teramoto, Shokichi³ 

[1] Kato Ladies Clin, Shinjuku Ku, Tokyo 1600023, Japan

[2] Kanazawa Univ, Grad Sch Med, Dept Obster & Gynecol, Kanazawa, Ishikawa 131, Japan

[3] Shinbashi Yume Clin, Minato Ku, Tokyo 1050004, Japan

关键词: blastocyst culture;    in-vitro fertilization;    minimal ovarian stimulation;    outcome prediction;    single embryo transfer;   

DOI  :  10.1016/j.rbmo.2014.06.007

来源: Elsevier

【 摘 要 】

The aim of this study was to establish a simple, objective blastocyst grading system using women's age and embryo developmental speed to predict clinical pregnancy after single vitrified-warmed blastocyst transfer. A 6-year retrospective cohort study was conducted in a private infertility centre. A total of 7341 single vitrified-armed blastocyst transfer cycles were included, divided into those carried out between 2006 and 2011 (6046 cycles) and 2012 (1295 cycles). Clinical pregnancy rate, ongoing pregnancy rate and delivery rates were stratified by women's age (<35, 35-37, 38-39, 40-41, 42-45 years) and time to blastocyst expansion (<120, 120-129, 130-139, 140-149, >149 h) as embryo developmental speed. In all the age groups, clinical pregnancy rate, ongoing pregnancy rate and delivery rates decreased as the embryo developmental speed decreased (P < 0.0001). A simple five-grade score based on women's age and embryo developmental speed was determined by actual clinical pregnancy rates observed in the 2006-2011 cohort. Subsequently, the novel grading score was validated in the 2012 cohort (1295 cycles), finding an excellent association. In conclusion, we established a novel blastocyst grading system using women's age and embryo developmental speed as objective parameters. (C) 2014 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

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