Fertility-preservation counselling and treatment for medical reasons: data from a multinational network of over 5000 women

REPRODUCTIVE BIOMEDICINE ONLINE

卷:31

Article

von Wolff, Michael¹  Dittrich, Ralf²  Liebenthron, Jana³  Nawroth, Frank⁴  Schuering, Andreas N.⁵  Bruckner, Thomas⁶  Germeyer, Ariane⁷ 

[1] Womens Univ Hosp, Div Gynaecol Endocrinol & Reprod Med, CH-3010 Bern, Switzerland

[2] Univ Erlangen Nurnberg, Womens Univ Hosp, D-91054 Erlangen, Germany

[3] Womens Univ Hosp, Div Gynaecol Endocrinol & Reprod Med, D-53127 Bonn, Germany

[4] Amedes, Ctr Fertil Prenatal Med Endocrinol & Osteol, D-20095 Hamburg, Germany

[5] Womens Univ Hosp, Infertil Ctr, Munster, Germany

[6] Heidelberg Univ, Inst Med Biometry & Informat, D-69120 Heidelberg, Germany

[7] Womens Univ Hosp, Div Gynaecol Endocrinol & Reprod Med, D-69120 Heidelberg, Germany

关键词: fertility preservation;    GnRH agonists;    oocyte;    ovarian stimulation;    ovarian tissue;    registry;   

DOI  :  10.1016/j.rbmo.2015.07.013

来源: Elsevier

【 摘 要 】

Fertility-preservation techniques for medical reasons are increasingly offered in national networks. Knowledge of the characteristics of counselled patients and techniques used are essential. The FertiPROTEKT network registry was analysed between 2007 and 2013, and included up to 85 university and non-university centres in Germany, Austria and Switzerland; 5159 women were counselled and 4060 women underwent fertility preservation. In 2013, fertility-preservation counselling for medical reasons increased significantly among nullipara and women aged between 21 and 35 years (n = 1043; P < 0.001). Frequency of GnRH applications slowly decreased, whereas tissue, oocytes and zygote cryopreservation increased. In 2013, women with breast cancer mainly opted for tissue freezing, whereas women with lymphoma opted for GnRH agonist. Women younger than 20 years predominantly opted for GnRH agonists and ovarian tissue cryopreservation; women aged between 20 and 40 years underwent a variety of techniques; and women over 40 years opted for GnRH agonists. The average number of aspirated oocytes per stimulation cycle decreased as age increased (< 30 years: 12.9; 31-35 years: 12.3; 36-46: 9.0; > 41 years: 5.7). For ovarian tissue cryopreservation, removal and cryopreservation of fewer than one ovary was preferred and carried out in 97% of cases in 2013. (C) 2015 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

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