Association of gene polymorphisms in the anti-Mullerian hormone signalling pathway with ovarian function: a systematic review and meta-analysis

REPRODUCTIVE BIOMEDICINE ONLINE

卷:39

Review

Chen, Ran^1,2,3,4  Xiong, Wei^1,2,3,4  Luo, Xiaoyan^1,2,3,4  Ma, Yaxian^1,2,3,4  Nie, Ying^1,2,3,4  Qiao, Xiaoyong^1,2,3,4  Chen, Hui^1,2,3,4  Hu, Ying^1,2,3,4  Xu, Liangzhi^1,2,3,4 

[1] Sichuan Univ, West China Univ Hosp 2, Dept Obstet & Gynecol, Chengdu 610041, Sichuan, Peoples R China

[2] Joint Lab Reprod Med Sichuan Univ Chinese Univ Ho, Chengdu 610041, Sichuan, Peoples R China

[3] Sichuan Univ, Key Lab Birth Defects & Related Dis Women & Child, Minist Educ, Chengdu 610041, Sichuan, Peoples R China

[4] Sichuan Univ, West China Univ Hosp 2, Reprod Endocrinol & Regulat Lab, Chengdu 610041, Sichuan, Peoples R China

关键词: Age at natural menopause;    AMH;    Anti-Mullerian hormone;    Ovarian reserve;    Polymorphism;    Primary ovarian insufficiency;   

DOI  :  10.1016/j.rbmo.2019.04.010

来源: Elsevier

【 摘 要 】

This systematic review evaluated whether single nucleotide polymorphisms of AMH and AMHRII genes are associated with ovarian function. A literature search of PubMed and Embase was complemented by hand searches in the reference lists. Eight studies involving 3155 participants were included in a meta-analysis and 10 studies included for description. For AMH c.146T>G polymorphism, no significant difference in serum anti-Mullerian hormone (AMH) levels was found between participants with different genotypes (weighted mean difference [WMD] 0.42, 95% confidence interval [CI] -0.16 to 0.99). Subgroup analyses showed similar results for the European region and in healthy and infertile populations. Regarding AMHRII -482 A>G, there was no significant difference in serum AMH levels between participants with A/A genotype and G/A or G/G genotype carriers (WMD -0.04, 95% CI -0.31 to 0.23). In subgroup analysis, an interesting trend was confirmed in healthy women and polycystic ovary syndrome (PCOS) patients (WMD -0.36, 95% CI -0.63 to -0.09, P = 0.009; WMD 0.46, 95% CI 0.15 to 0.77, P = 0.004). The review suggests that AMH c.146T>G is not associated with AMH levels, while AMHRII -482 A>G may be related to AMH levels in PCOS and healthy subgroups. However, the impact of polymorphisms in the AMH signalling pathway on ovarian function still requires further investigation.

【 授权许可】

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