External validation of nomogram for the decline in serum anti-Mullerian hormone in women: a population study of 15,834 infertility patients

REPRODUCTIVE BIOMEDICINE ONLINE

卷:23

Article

Nelson, Scott M.¹  Messow, Martina C.²  McConnachie, Alex²  Wallace, Hamish³  Kelsey, Thomas⁴  Fleming, R.⁵  Leader, B.⁶ 

[1] Univ Glasgow, Ctr Populat & Hlth Sci, Glasgow G12 8QQ, Lanark, Scotland

[2] Univ Glasgow, Robertson Ctr Biostat, Glasgow G12 8QQ, Lanark, Scotland

[3] Univ Edinburgh, Div Reprod & Dev Sci, Sect Child Life & Hlth, Edinburgh, Midlothian, Scotland

[4] Univ St Andrews, Sch Comp Sci, St Andrews, Fife, Scotland

[5] GCRM Ltd, Glasgow, Lanark, Scotland

[6] ReproSource Inc, Div Clin Res, Woburn, MA USA

关键词: AMH;    age;    nomogram;    external validation;   

DOI  :  10.1016/j.rbmo.2011.05.006

来源: Elsevier

【 摘 要 】

The value of anti-mullerian hormone (AMH) as a marker of the ovarian reserve is becoming clear in a range of clinical contexts. This study reports the external validation of a quadratic model-based AMH-age nomogram using a cohort of 15,834 US women. All models previously investigated for the decline in ovarian reserve (i.e. linear, bi-linear, decay curve, power and quadratic models) tended to overestimate AMH by approximately 11% versus the published nomogram, indicating some between-population heterogeneity. Bootstrapping of 1000 datasets indicated that the quadratic model provided the best fit, confirming the choice of this model in the AMH-age nomogram. This nomogram can therefore be used with confidence for the interpretation of AMH in clinical populations. (C) 2011, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

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