Neonatal and neurodevelopmental outcome of children aged 3-10 years born following assisted oocyte activation

REPRODUCTIVE BIOMEDICINE ONLINE

卷:28

Article

Vanden Meerschaut, Frauke¹  D'Haeseleer, Evelien²  Gysels, Hannelore³  Thienpont, Ylenia³  Dewitte, Griet⁴  Heindryckx, Bjorn¹  Oostra, An⁴  Roeyers, Herbert³  Van Lierde, Kristiane²  De Sutter, Petra¹ 

[1] Univ Hosp Ghent, Dept Reprod Med, B-9000 Ghent, Belgium

[2] Univ Hosp Ghent, Dept Otorhinolaryngol & Head & Neck Surg, B-9000 Ghent, Belgium

[3] Univ Ghent, Dept Expt Clin & Hlth Psychol, Res Grp Dev Disorders, B-9000 Ghent, Belgium

[4] Ctr Dev Disorders, B-9000 Ghent, Belgium

关键词: assisted oocyte activation;    child follow up;    failed fertilization;    ICSI;    ionomycine;   

DOI  :  10.1016/j.rbmo.2013.07.013

来源: Elsevier

【 摘 要 】

Assisted oocyte activation (AOA) using a calcium ionophore has been used for more than a decade following intracytoplasmic sperm injection (ICSI) fertilization failure. However, since AOA does not mimic precisely the physiological fertilization process, concerns exist about its use in human assisted reproduction. This study assessed the neonatal and neurodevelopmental outcome of children aged >= 3 years who had been born following AOA in our centre. Twenty-one children participated in the study (81% response rate; mean age 63.6 +/- 21.07 months). Neonatal data were collected via questionnaires. Neurodevelopmental outcome was tested using the Reynell Developmental Language Scales or Clinical Evaluation of Language Fundamentals, Wechsler Preschool and Primary Scale of Intelligence or Wechsler Intelligence Scale for Children, and the Movement Assessment Battery for Children III. Behaviour was scored by the Social Communication Questionnaire, the Child Behaviour Checklist and the Teachers Report Form. For all tests and questionnaires, the mean outcomes lay within the expected ranges. These are first data on the developmental outcome of AOA children. The high response rate and the robustness of the tests support the data, which are reassuring although still considered preliminary. Therefore, AOA should still be performed only in selected couples. (C) 2013, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

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