期刊论文详细信息
REPRODUCTIVE BIOMEDICINE ONLINE 卷:36
Establishment and validation of a score to predict ovarian response to stimulation in IVF
Article
Chalumeau, Clelia1  Moreau, Jessika1,2  Gatimel, Nicolas1,2  Cohade, Clementine1  Lesourd, Florence1  Parinaud, Jean1,2  Leandri, Roger1,2 
[1] CHU Toulouse, Med Reprod, F-31059 Toulouse, France
[2] Univ Paul Sabatier, Grp Rech Fertilite Humaine EA 3694, F-31059 Toulouse, France
关键词: Anti-Mullerian hormone;    Antral follicle count;    FSH;    Gonadotrophin-releasing hormone antagonist protocol;    Ovarian reserve;    Ovarian stimulation;   
DOI  :  10.1016/j.rbmo.2017.09.011
来源: Elsevier
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【 摘 要 】

This study aimed to integrate clinical and biological parameters in a score able to predict ovarian response to stimulation for IVF in gonadotrophin-releasing hormone (GnRH) antagonist protocols. A progressive discriminant analysis to establish a score including the main clinical and biological parameters predicting ovarian response was performed by retrospectively analysing data from the first ovarian stimulation cycle of 494 patients. The score was validated in a prospectively enrolled, independent set of 257 patients undergoing their first ovarian stimulation cycle. All ovarian stimulations were performed using a combination of GnRH antagonist and recombinant FSH. Ovarian response was assessed through ovarian sensitivity index (OSI). Parameters from the patients' database were classified according to correlation with OSI: the progressive discriminant analysis resulted in the following calculation: score = 0.192 - (0.004 x FSH (IU/l)) + (0.012 x LH:FSH ratio) + (0.002 x AMH (ng/ml)) - (0.002 x BMI (kg/m2)) + (0.001 x AFC) - (0.002 x age (years)). This score was significantly correlated with OSI in the retrospective (r = 0.599; P < 0.0001) and prospective (r = 0.584; P < 0.0001) studies. In conclusion, the score including clinical and biological parameters could explain 60% of the variance in ovarian response to stimulation. (c) 2017 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

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