Comparison of stimulated versus modified natural cycles for endometrial preparation prior to frozen embryo transfer: a randomized controlled trial

REPRODUCTIVE BIOMEDICINE ONLINE

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Article

Labrosse, Julie¹  Lobersztajn, Annina^1,2  Pietin-Vialle, Claire¹  Villette, Claire¹  Lucie Dessapt, Anne^1,3  Jung, Camille⁴  Brussieux, Maxime⁴  Bry-Gauillard, Helene¹  Pasquier, Maud¹  Massin, Nathalie¹ 

[1] Univ Paris Est Creteil, Ctr Hosp Intercommunal Creteil, Dept Gynecol Obstet & Reprod Med, Creteil, France

[2] Hop Pierre Rouques Bluets, Dept Gynecol Obstet & Reprod Med, Paris, France

[3] IVI Clin Barcelona, Barcelona, Spain

[4] Univ Paris Est Creteil, Ctr Hosp Intercommunal Creteil, Clin Res Ctr, Creteil, France

关键词: Endometrial preparation;    FertiQol;    Frozen embryo transfer;    Modified natural cycle;    Stimulated cycle;   

DOI  :  10.1016/j.rbmo.2020.01.007

来源: Elsevier

【 摘 要 】

Research question: To compare stimulated cycle (STC) versus modified natural cycle (MNC) for endometrial preparation prior to frozen embryo transfer (FET) in terms of convenience and efficacy. Design: Prospective, open-label, randomized controlled study including 119 patients aged 20-38 years, undergoing intra-conjugal IVF/intracytoplasmic sperm injection, having regular cycles, at least two day 2 or day 3 frozen embryos, for whom it was the first or second FET performed, randomized to either MNC (n = 59) or STC (n = 60). Monitoring consisted of ultrasound and hormonal measurements. The number of monitoring visits required was compared between the two groups. Results: STC required a significantly lower number of monitoring visits compared with MNC (3.6 +/- 0.9 versus 4.4 +/- 1.1, respectively, P < 0.0001), a lower number of blood tests (2.7 +/- 0.8 versus 3.5 +/- 1.0, respectively, P < 0.0001) and of ultrasounds (1.2 +/- 0.4 versus 1.5 +/- 0.6, respectively, P = 0.0039). FET during 'non-opening' hours (22.6% versus 275%, respectively, P = 0.32) and cancellation rates (11.7% versus 11.9%, respectively, P = 0.97) were comparable between the STC and MNC groups. No difference concerning HCG-positive rates (34.0% versus 23.1%, respectively, P = 0.22) nor live birth rates (24.5% for STC versus 23.1% for MNC, respectively, P = 0.86) was observed. Quality of life as defined by the FertiQol score was not different (P > 0.05 for each item). Conclusion: Altogether, these findings can be used for everyday clinical practice to better inform patients when deciding on the protocol to use for FET. These results suggest that MNC is a good option for patients reluctant to have injections, but requires increased monitoring. STC may offer more flexibility for patients and IVF centres.

【 授权许可】

Free