Reproductive characteristics of women diagnosed with premature ovarian insufficiency

REPRODUCTIVE BIOMEDICINE ONLINE

卷:32

Article

Daan, Nadine M. P.¹  Hoek, Annemieke²  Corpeleijn, Eva³  Eijkemans, Marinus J. C.^1,4  Broekmans, Frank J.¹  Fauser, Bart C. J. M.¹  Koster, Maria P. H.¹ 

[1] Univ Med Ctr Utrecht, Dept Reprod Med & Gynaecol, PB 85500, NL-3508 GA Utrecht, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, Dept Obstet & Gynaecol, PB 30001, NL-9700 RB Groningen, Netherlands

[3] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, PB 30001, NL-9700 RB Groningen, Netherlands

[4] Julius Ctr Hlth Sci & Primary Care, PB 85500, NL-3508 GA Utrecht, Netherlands

关键词: menopause;    POI;    reproductive characteristics;    time to pregnancy;   

DOI  :  10.1016/j.rbmo.2015.11.009

来源: Elsevier

【 摘 要 】

In this retrospective cohort study (n = 479), the proportion of women with premature ovarian insufficiency (POI) who conceived was assessed, the reproductive characteristics of women with POI who had previously been pregnant or had never been pregnant compared, and the interval between last conception and the menopause in women with POI who had become pregnant assessed. Time to pregnancy and maternal age at first childbirth were compared between women with POI and population-based controls (n = 2304). Women with POI who had previously been pregnant (n = 249 [52%]) experienced menopause at a later age compared with controls (35.0 years: interquartile range [IQR] 32.0-37.5 versus 30.0 years [IQR 23.0-35.0]; P < 0.001). The median interval between last conception and menopause in the former group was 4.0 years (IQR 1.0-8.0). Time to pregnancy did not differ between women with POI and controls. Women with POI were younger at first childbirth compared with controls (27.3 years [IQR 23.4-30.5] versus 29.2 years [26.4-32.0]; P < 0.001). The reproductive capacity of young women with POI is comparable to women in the general population, up until a given age; thereafter a rapid loss of the potential to conceive occurs. (C) 2015 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

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