Multifetal reduction of triplets to twins compared with non-reduced twins: a meta-analysis

REPRODUCTIVE BIOMEDICINE ONLINE

卷:35

Article

Zipori, Yaniv¹  Haas, Jigal^2,3  Berger, Howard¹  Barzilay, Eran⁴ 

[1] Univ Toronto, St Michaels Hosp, Dept Obstet & Gynecol, Div Maternal Fetal Med, Toronto, ON, Canada

[2] Univ Toronto, Div Reprod Sci, Toronto, ON, Canada

[3] TRIO Fertil Partners, Toronto, ON, Canada

[4] Tel Aviv Univ, Sackler Sch Med, Sheba Med Ctr, Dept Obstet & Gynecol, Tel Aviv, Israel

关键词: Meta-analysis;    Multifetal pregnancy reduction;    Non-reduced twins;    Perinatal outcome;    Triplets;   

DOI  :  10.1016/j.rbmo.2017.04.001

来源: Elsevier

【 摘 要 】

The current systematic review and meta-analysis evaluates the perinatal outcomes in twin pregnancies following multifetal pregnancy reduction IMPRI compared with non-reduced twins. We considered all studies comparing perinatal outcomes of twin pregnancies following MPR to non-reduced twin pregnancies. Our search yielded 639 publications, of which 91 were assessed for eligibility. A total of 22 studies met our inclusion criteria. Overall, fetal reduction of triplets to twins resulted in comparable perinatal outcomes to non-reduced twins with regards to gestational age and birthweight at delivery, pregnancy loss prior to 24 weeks, as well as the development of gestational diabetes and hypertensive disorders of pregnancy. Of all outcomes, only the Caesarean section rate was significantly higher in the MPR group compared with the non-reduced twins group with an odds ratio of 1.95 (195% confidence interval 1.33-2.871). This meta-analysis suggests that MPR of triplet pregnancies to twins is associated with comparable perinatal outcomes to that of non-reduced twins. This information can further help in guiding, and probably reassuring, clinician and patient decision-making when faced with high-order multifetal pregnancies. (C) 2017 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

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