Maternal control of genomic imprint maintenance

REPRODUCTIVE BIOMEDICINE ONLINE

卷:27

Article

Mann, Mellissa R. W.^1,2,3 

[1] Univ Western Ontario, Dept Obstet & Gynecol, Schulich Sch Med & Dent, London, ON, Canada

[2] Univ Western Ontario, Dept Biochem, Schulich Sch Med & Dent, London, ON, Canada

[3] Childrens Hlth Res Inst, London, ON N6C 2V5, Canada

关键词: assisted reproduction technologies;    DNA methylation;    genomic imprinting;    maternal-effect genes;    preimplantation development;   

DOI  :  10.1016/j.rbmo.2013.06.004

来源: Elsevier

【 摘 要 】

Genomic imprinting is a specialized transcriptional phenomenon that employs epigenetic mechanisms to facilitate parental-specific expression. Perturbations in parental epigenetic asymmetry can lead to the development of imprinting disorders, such as Beckwith-Wiedemann syndrome and Angelman syndrome. DNA methylation is one of the most widely studied epigenetic marks that characterizes imprinted regions. During gametogenesis and early embryogenesis, imprinted methylation undergoes a cycle of erasure, acquisition and maintenance. Gamete and embryo manipulations for the purpose of assisted reproduction are performed during these reprogramming events and may lead to their disruption. Recent studies point to the role of maternal-effect proteins in imprinted gene regulation. Studies are now required to increase understanding of how these factors regulate genomic imprinting as well as how assisted reproduction technologies may alter their function. (C) 2013, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

Free