Do uterine fibroids affect IVF outcomes?

REPRODUCTIVE BIOMEDICINE ONLINE

卷:15

Article

Vimercati, Antonella ; Scioscia, Marco ; Lorusso, Filomenamila ; Laera, Anna Franca ; Lamanna, Giuseppina ; Coluccia, Alfredo ; Bettocchi, Stefano ; Selvaggi, Luigi ; Depalo, Raffaella

关键词: assisted reproductive technology procedures;    ICSI;    IVF;    myomectomy;    uterine fibroids;   

DOI  :  10.1016/S1472-6483(10)60536-6

来源: Elsevier

【 摘 要 】

The effect of myomectomy on implantation and pregnancy rates prior to assisted reproduction treatments is controversial. This study was designed to assess clinical outcomes of lVF cycles in women with uterine fibroids. A retrospective single-centre assessment of clinical outcomes of IVF/intracytoplasmic sperm injection (ICSI) treatments in infertile women in a 4-year span was carried out. All patients underwent detailed transvaginal ultrasound and hysteroscopy to precisely identify presence, location and intracavitary growth of uterine fibroids. Cumulative pregnancy, ongoing pregnancy and live birth rates were considered primary outcome measurements. Fifty-one women with fibroids (97 treatment cycles), 63 patients with previous myomectomy (127 cycles), and 106 infertile women who did not demonstrate fibroids anywhere in the uterus (215 cycles) were considered for the analysis. No significant difference was found for pregnancy and live birth rates between groups. Women with fibroids >4 cm required an increased number of cycles to obtain an ongoing pregnancy, compared with the other groups. The data do not support pre-IVF myomectomy in women with small-to-moderate uterine fibroids, regardless of their location. This represents valuable information in the counselling of women with fibroids before reproductive assisted cycles.

【 授权许可】

Free