Failed fertilization after clinical intracytoplasmic sperm injection

REPRODUCTIVE BIOMEDICINE ONLINE

卷:20

Review

Javed, Murid¹  Esfandiari, Navid^1,2  Casper, Robert F.^1,2 

[1] TCART, Toronto, ON M5S 2X9, Canada

[2] Univ Toronto, Dept Obstet & Gynaecol, Div Reprod Sci, Toronto, ON, Canada

关键词: failed fertilization;    infertility;    intracytoplasmic sperm injection;    in-vitro fertilization;   

DOI  :  10.1016/j.rbmo.2009.10.010

来源: Elsevier

【 摘 要 】

Intracytoplasmic sperm injection (ICSI) has resulted in pregnancy and birth for many couples, including those with severe mate factor infertility. However, even after ICSI, complete failure of fertilization occurs in 1-3% of cycles. Most cases occur due to tow number of mature oocytes, failure of oocyte activation or non-availability of appropriate spermatozoa for injection. Given the significant emotional and financial involvement in assisted reproductive cycles, failure of fertilization in all mature oocytes is a distressful event. It is not predictable. Since follow-up ICSI cycles result in fertilization in 85% of cases, repeated ICSI attempts are suggested. Physicians should counsel patients experiencing repeated failure of fertilization after ICSI cycles about available options including donated oocytes/embryos, donor sperm insemination, adoption or remaining childless if these choices are not acceptable due to religious or ethical reasons. This review discusses the causes and remedies for failed fertilization after clinical ICSI. (C) 2009, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

Free