Second-generation preimplantation genetic testing for aneuploidy in assisted reproduction: a SWOT analysis

REPRODUCTIVE BIOMEDICINE ONLINE

卷:39

Review

Bellver, Jose^1,2  Bosch, Ernesto^1,2  Jose Espinos, Juan^3,4  Fabregues, Francisco⁵  Fontes, Juan⁶  Garcia-Velasco, Juan⁷  Llacer, Joaquin⁸  Requena, Antonio⁷  Checa, Miguel Angel⁹ 

[1] Univ Valencia, Fac Med, Inst Valenciano Infertilidad, Valencia, Spain

[2] Univ Valencia, Fac Med, Dept Pediat Obstet & Ginecol, Valencia, Spain

[3] Fertty, Barcelona, Spain

[4] Hosp Santa Creu & Sant Pau, Barcelona, Spain

[5] Hosp Clin Barcelona, Inst Clin Gynecol Obstet & Neonatol, Barcelona, Spain

[6] Hosp Univ Virgen de las Nieves, Granada, Spain

[7] IVI RMA Madrid, Madrid, Spain

[8] Inst Bernabeu Alicante, Alicante, Spain

[9] Hosp del Mar, Parc Salut Mar, Barcelona, Spain

关键词: Assisted reproduction;    Blastocyst biopsy;    Implantation;    Infertility;    Live birth;    Preimplantation genetic testing;   

DOI  :  10.1016/j.rbmo.2019.07.037

来源: Elsevier

【 摘 要 】

Second-generation preimplantation genetic testing for aneuploidy (PGT-A 2.0) in patients with an unfavourable reproductive and IVF prognosis is becoming common practice, with the aim of improving reproductive outcomes. However, there is still no clear evidence on the possible advantages and drawbacks with regard to this procedure. In this discussion paper, based on a SWOT (strengths, weaknesses, opportunities, threats) analysis, the different aspects of this strategy are evaluated. Current evidence suggests that PGT-A 2.0 should not at present have an indiscriminate application, but it might be indicated in cases in which the risk of aneuploidy is increased.

【 授权许可】

Free