期刊论文详细信息
REPRODUCTIVE BIOMEDICINE ONLINE 卷:42
Impaired implantation in endometriosis compared with couples with male subfertility after transfer of equal quality embryos: a matched cohort study
Article; Proceedings Paper
Blank, Celine1,2,3  Deboever, Charlotte1  Decroos, Eva1  DeCroo, Ilse1  Tilleman, Kelly1  De Sutter, Petra1  Mischi, Massimo2  Schoot, Benedictus Christiaan1,2,3 
[1] Ghent Univ Hosp, Dept Reprod Med, De Pintelaan 185, B-9000 Ghent, Belgium
[2] Eindhoven Tech Univ, Dept Elect Engn Signal Proc Syst, 19 Flux,Postbus 513, NL-5600 MB Eindhoven, Netherlands
[3] Catharina Hosp, Dept Obstet & Gynecol, Michelangelolaan 2, NL-5623 E Eindhoven, Netherlands
关键词: Embryo quality;    Endometriosis;    Implantation;    Live birth rate;    Matched cohort;    Pregnancy rate;   
DOI  :  10.1016/j.rbmo.2020.08.034
来源: Elsevier
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【 摘 要 】

Research question: Is implantation impaired in patients with endometriosis undergoing IVF and intracytoplasmatic sperm injection (ICSI) cycles? Design: A retrospective matched cohort study was carried out on IVF/ICSI cycles with fresh single embryo transfer at the Department of Assisted Reproductive Medicine, Ghent University Hospital, Belgium, between July 2015 and August 2017 (n = 1053). A total of 118 endometriosis cases were matched 1:1 to 118 couples diagnosed with male subfertility and stratified by embryo quality (identical ALPHA grading categories), female age (+/- 1 year) and parity (+/- 1 delivery). Transvaginal ultrasound, magnetic resonance imaging or laparoscopy was used to diagnosed endometriosis, and the revised American Society for Reproductive Medicine score was used to classify the endometriosis into grade I/II versus grade III/IV. Male subfertility was defined in accordance with World Health Organization criteria (fifth edition). Results: Compared with endometriosis cases, control couples with male subfertility had significantly higher rates of positive HCG test on day 16 (P = 0.047, OR 2.077, CI 1.009 to 4.276), ongoing implantation (defined as a positive fetal heart rate on transvaginal ultrasound at a gestational age of at least 6.5-7 weeks) (P = 0.038, OR 2.265, CI 1.048 to 4.893), ongoing pregnancy (defined by a vital pregnancy at 11 weeks) (P = 0.046, OR 2.292, CI 1.016 to 5.173) and live birth (P = 0.043, OR 2.502, CI 1.029 to 6.087). Conclusions: After matching for embryo quality, woman's age and parity, rates of positive HCG tests, ongoing implantation, ongoing pregnancy and live birth were more than twice as high in the control group compared with the endometriosis group.

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