First trimester depression and/or anxiety disorders increase the risk of low birthweight in IVF offspring: a prospective cohort study

REPRODUCTIVE BIOMEDICINE ONLINE

卷:39

Article

Lang, Jingwen^1,2  Zhang, Bingqian^3,4,5  Meng, Yueru^3,4,5  Du, Yanzhi^1,2  Cui, Linlin^3,4,5  Li, Weiping^1,2 

[1] Shanghai Jiao Tong Univ, Ctr Reprod Med, Ren Ji Hosp, Sch Med, Shanghai 200135, Peoples R China

[2] Shanghai Key Lab Assisted Reprod & Reprod Genet, Shanghai 200135, Peoples R China

[3] Shandong Univ, Ctr Reprod Med, Prov Hosp, Shandong Prov Key Lab Reprod Med, Jinan 250001, Shandong, Peoples R China

[4] Minist Educ, Key Lab Reprod Endocrinol, Jinan 250001, Shandong, Peoples R China

[5] Natl Res Ctr Assisted Reprod Technol & Reprod Gen, Jinan 250001, Shandong, Peoples R China

关键词: Anxiety;    Depression;    IVF;    Low birthweight;    Maternal;   

DOI  :  10.1016/j.rbmo.2019.09.002

来源: Elsevier

【 摘 要 】

Research question: Are maternal depression and/or anxiety disorders (MDAD) before and during pregnancy associated with IVF outcomes? Design: A total of 5661 women starting their first IVF cycle between 15 August 2014 and 31 December 2015 were pooled from a prospective cohort of IVF-conceived children. The self-rating depression scale (SDS) and self-rating anxiety scale (SAS) were used to determine MDAD. IVF outcomes were compared between MDAD+ and MDAD- groups. Results: A total of 10.3% (572/5556) of women had MDAD before IVF (bMDAD). The fertilization rate was lower in the bMDAD+ group (59.41 +/- 22.11% versus 61.72 +/- 22.18%, P-adjust < 0.05). No difference was found in the other IVF outcomes. Pregnancy and neonatal outcomes in women with singleton live births were similar between the two groups. A total of 174% (347) women with singleton live births had MDAD during the first trimester (pMDAD). Birthweight (3383 +/- 556 g versus 3447 +/- 518 g, P-adjust < 0.05) was lower and incidence of low birthweight (LBW) (6.9% versus 3.3%, P-adjust < 0.01) was higher in the pMDAD group. After adjustment for potential confounders (gestational age, maternal age, maternal pre-pregnancy body mass index, threatened abortion, hypertensive disorder complicating pregnancy and gestational diabetes mellitus), pMDAD remained significantly associated with LBW (odds ratio [OR] 2.50, 95% confidence interval [CI]1.16-5.42, P-adjust < 0.05). The preconception psychological state in the pMDAD group did not demonstrate any additional impact on neonatal outcomes. Conclusions: MDAD during the first trimester is associated with increased risk of LBW in offspring, whether preconception MDAD exists or not.

【 授权许可】

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