Effects of treatment of ectopic pregnancy with methotrexate or salpingectomy in the subsequent IVF cycle

REPRODUCTIVE BIOMEDICINE ONLINE

卷:26

Article

Wiser, Amir^1,6,7  Gilbert, Audrey¹  Nahum, Ravit²  Orvieto, Raoul²  Haas, Jigal³  Hourvitz, Ariel³  Weissman, Ariel⁴  Younes, Grace⁵  Dirnfeld, Martha⁵  Hershko, Anat⁶  Shulman, Adrian⁶  Tsafrir, Avi⁸  Holzer, Hananel¹  Shalom-Paz, Einat¹  Tulandi, Togas¹ 

[1] McGill Univ Montreal, Dept Obstet & Gynecol, Quebec City, PQ, Canada

[2] Askelon & Ben Gurion Univ Negev, Brazilai Med Ctr, Beer Sheva, Israel

[3] Tel Aviv Univ, Sheba Med Ctr, Tel Hashomer, Israel

[4] Tel Aviv Univ, Wolfson Med Ctr, Holon, Israel

[5] Carmel Hosp, Haifa, Israel

[6] Tel Aviv Univ, Meir Med Ctr, Kefar Sava, Israel

[7] Tel Aviv Univ, Meir Med Ctr, Sackler Fac Med, IVF Unit, Kefar Sava, Israel

[8] Sharei Zedek, Jerusalem, Israel

关键词: ectopic pregnancy;    IVF;    methotrexate;    ovarian response;    salpingectomy;   

DOI  :  10.1016/j.rbmo.2013.01.018

来源: Elsevier

【 摘 要 】

Ectopic pregnancy is a known risk for patients treated with IVF. The objective of this study was to evaluate the effect of methotrexate (MTX) and laparoscopic salpingectomy as treatments of ectopic pregnancy on ovarian response during IVF cycles. Data of all women treated for ectopic pregnancy as a result of IVF treatment were evaluated; the study included women who had an unruptured ectopic pregnancy after IVF treatment that was treated with either MTX or laparoscopic salpingectomy and underwent a subsequent IVF cycle. The main outcome measures were baseline serum FSH concentrations and ovarian response in the subsequent IVF cycle after treatment of ectopic pregnancy. Of a total of 58 patients, 36 were previously treated with MTX and 22 others by salpingectomy. No significant differences were observed between the MTX and the salpingectomy groups in the parameters of ovarian response in the subsequent IVF cycle. Repeat ectopic pregnancy was encountered in one patient in each group with a total rate of 3.4% (2/58). No significant differences were found in the outcomes of the subsequent pregnancy after treatment with MTX or salpingectomy. It is concluded that neither prior MTX treatment nor salpingectomy affect ovarian response in the subsequent IVF cycle. (C) 2013, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

Free