High-quality embryos retain their implantation capability in overweight women

REPRODUCTIVE BIOMEDICINE ONLINE

卷:21

Article

Farhi, Jacob¹ 

[1] Helen Schneider Hosp Women, Infertil & IVF Unit, Rabin Med Ctr, Dept Obstet & Gynecol, IL-49100 Petah Tiqwa, Israel

关键词: BMI;    implantation;    IVF;    overweight;    pregnancy complications;   

DOI  :  10.1016/j.rbmo.2010.06.040

来源: Elsevier

【 摘 要 】

To assess the effect of obesity on implantation rate, pregnancy rate and course of pregnancy in young women undergoing IVF in whom only high-quality embryos were transferred, a cohort study included women attending the IVF unit in 2006-2007 with favourable parameters to achieve pregnancy (<38 years, fewer than three IVF cycles, transfer of two high-quality embryos), grouped by body mass index (BMI). Of 230 women, 160 had a BMI <= 25 kg/m(2) (mean 21.6 +/- 2.2) and 73 had BMI >25 kg/m(2) (mean 29.5 +/- 3.7). The overweight group had a higher consumption of gonadotrophins during stimulation. There were no between-group differences in treatment protocols, duration of gonadotrophin stimulation, maximal oestradiol concentrations, endometrial thickness and number of oocytes retrieved/fertilized, or in rates of pregnancy (51.3%, 52.1%), implantation (34.5%, 37.5%), multiple pregnancy, and abortion. Rate of gestational diabetes or pregnancy-induced hypertension was higher in the overweight group (23.3%, 8.2%; P = 0.045). Within the overweight group, those with multiple pregnancies were at highest risk (31.3%, 6.9%; P = 0.031). In conclusion, implantation and pregnancy rates are not compromised in overweight women when high-quality embryos are transferred. However, in overweight women, pregnancy complications remain high, mainly in those with multiple pregnancies. (C) 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

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