A cluster analysis of tic symptoms in children and adults with Tourette syndrome: Clinical correlates and treatment outcome

PSYCHIATRY RESEARCH

卷:210

Article

McGuire, Joseph F.¹  Nyirabahizi, Epiphanie^2,3  Kircanski, Katharina⁴  Piacentini, John⁵  Peterson, Alan L.⁶  Woods, Douglas W.⁷  Wilhelm, Sabine^8,9  Walkup, John T.¹⁰  Scahill, Lawrence¹¹ 

[1] Univ S Florida, Dept Psychol, Tampa, FL 33620 USA

[2] Yale Univ, Dept Epidemiol, New Haven, CT USA

[3] Yale Univ, Dept Publ Hlth, New Haven, CT USA

[4] Stanford Univ, Dept Psychol, Stanford, CA 94305 USA

[5] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90024 USA

[6] Univ Texas Hlth Sci Ctr San Antonio, Dept Psychiat, San Antonio, TX 78229 USA

[7] Univ Wisconsin, Dept Psychol, Milwaukee, WI 53201 USA

[8] Massachusetts Gen Hosp, Boston, MA 02114 USA

[9] Harvard Univ, Sch Med, Boston, MA USA

[10] Cornell Univ, Weil Cornell Med Coll, Ithaca, NY USA

[11] Emory Univ, Sch Med, Marcus Ctr, Atlanta, GA 30329 USA

关键词: Habit reversal training;    Comprehensive behavioral intervention for tics;    Tic symptom profiles;    Chronic tic disorders;    Treatment outcome;    Cluster analysis;   

DOI  :  10.1016/j.psychres.2013.09.021

来源: Elsevier

【 摘 要 】

Cluster analytic methods have examined the symptom presentation of chronic tic disorders (CTDs), with limited agreement across studies. The present study investigated patterns, clinical correlates, and treatment outcome of tic symptoms. 239 youth and adults with CTDs completed a battery of assessments at baseline to determine diagnoses, tic severity, and clinical characteristics. Participants were randomly assigned to receive either a comprehensive behavioral intervention for tics (CBIT) or psychoeducation and supportive therapy (PST). A cluster analysis was conducted on the baseline Yale Global Tic Severity Scale (YGTSS) symptom checklist to identify the constellations of tic symptoms. Four tic clusters were identified: Impulse Control and Complex Phonic Tics; Complex Motor Tics; Simple Head Motor/Vocal Tics; and Primarily Simple Motor Tics. Frequencies of tic symptoms showed few differences across youth and adults. Tic clusters had small associations with clinical characteristics and showed no associations to the presence of coexisting psychiatric conditions. Cluster membership scores did not predict treatment response to CBIT or tic severity reductions. Tic symptoms distinctly cluster with little difference across youth and adults, or coexisting conditions. This study, which is the first to examine tic clusters and response to treatment, suggested that tic symptom profiles respond equally well to CBIT. Clinical trials. gov. identifiers: NCT00218777; NCT00231985. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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