Striatal volume changes in a rat model of childhood attention-deficit/hyperactivity disorder

PSYCHIATRY RESEARCH

卷:179

Article

Hsu, Ju-Wei²  Lee, Li-Ching³  Chen, Ruei-Feng^4,5  Yen, Chen-Tung^4,5  Chen, Ying-Sheue²  Tsai, Meng-Li¹ 

[1] Natl Ilan Univ, Dept Biomechatron Engn, Ilan 260, Taiwan

[2] Taipei Vet Gen Hosp, Dept Psychiat, Taipei, Taiwan

[3] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[4] Natl Taiwan Univ, Inst Zool, Taipei 10764, Taiwan

[5] Natl Taiwan Univ, Dept Life Sci, Taipei 10764, Taiwan

关键词: Spontaneously hypertensive rat;    Striatum;    Caudate-putamen;   

DOI  :  10.1016/j.psychres.2009.08.008

来源: Elsevier

【 摘 要 】

Attention-deficit/hyperactivity disorder (ADHD) is one of the most common childhood neuropsychiatric disorders. Based on neuroimaging studies, the striatum is reported to be abnormal in size, but it is still not clear how they change during developmental stages. Spontaneously hypertensive rats (SHRs) are the commonly used animal model for ADHD. We investigated volume differences of the striatum at various ages before puberty in SHRs versus a control strain, Wistar-Kyoto rats (WKYs). Volumes of the bilateral striatum were measured using micrographs of Nissl-stained serial sections in both strains of rats at the ages of 4, 5, 6, 7, 8, 9, and 10 weeks (n = 4, each strain at each age). The results demonstrated that the age of a significant striatal volume difference between SHRs and WKYs was 5 weeks; however, there was no significant difference for the corresponding total brain volume, at each matched age. It suggested that the timing for striatal abnormalities in ADHD occurs during an early stage of childhood. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

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