Inflammatory markers in antipsychotic-naive patients with nonaffective psychosis and deficit vs. nondeficit features

PSYCHIATRY RESEARCH

卷:198

Article

Garcia-Rizo, Clemente¹  Fernandez-Egea, Emilio^2,3  Oliveira, Cristina¹  Justicia, Azucena²  Bernardo, Miguel^1,4,7  Kirkpatrick, Brian^5,6 

[1] Univ Barcelona, Hosp Clin, Inst Neurosci, Schizophrenia Program,Dept Psychiat, E-08036 Barcelona, Spain

[2] Univ Cambridge, Addenbrookes Hosp, Dept Psychiat, Cambridge CB2 0QQ, England

[3] Cambridgeshire & Peterborough NHS Fdn Trust, Huntingdon PE29 3RJ, England

[4] Inst Biomed Res Agusti Pi i Sunyer IDIBAPS, Barcelona, Spain

[5] Texas A&M Univ, Coll Med, Dept Psychiat, Temple, TX 76508 USA

[6] Scott & White Healthcare, Temple, TX USA

[7] CIBERSAM, Madrid, Spain

关键词: Deficit schizophrenia;    Interleukin 6;    C-reactive protein;    Glucose tolerance;    Negative symptoms;    First episode psychosis;   

DOI  :  10.1016/j.psychres.2011.08.014

来源: Elsevier

【 摘 要 】

Newly diagnosed, antipsychotic-naive patients with nonaffective psychosis appear to have increases in pro-inflammatory cytokines. Patients characterized by primary, enduring negative symptoms (deficit symptoms) differ from patients without such features with regard to course of illness, treatment response, risk factors and metabolic disturbances. We hypothesized that they would also differ on concentrations of the inflammatory markers interleukin-6 (IL6) and C-reactive protein (CRP). Newly diagnosed, antipsychotic-naive patients with nonaffective psychosis were categorized into deficit (N = 20) and nondeficit (N = 42) groups, and were matched on age, gender, body mass index, smoking, cortisol level, socioeconomic status, and the severity of psychotic symptoms. Fasting concentrations of IL6 were significantly higher in deficit (mean [S.D.]) (8.0 pg/ml [12.7]) than nondeficit patients (0.3 pg/ml [1.3]). CRP levels were also significantly higher in the deficit patients (0.3 mg/dl [0.4]) vs. (0.2 mg/dl [0.4]), respectively. In contrast, 2-h glucose concentrations (2HG) in a glucose tolerance test were lower in the deficit than the nondeficit group. Our results show a double dissociation with regard to glucose intolerance and inflammation: the deficit group has greater inflammation, but less severe glucose intolerance. These results provide further evidence for the validity of the deficit/nondeficit categorization. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

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